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- W2917834013 abstract "Abstract This paper demonstrates an efficient, green and convenient strategy for the synthesis of densely functionalized biologically important spiroxyindoles. This facile step economic synthetic protocol involves one‐pot three component condensation of functionalized isatins, malononitrile and C−H activated carbonyl compounds in the presence of Caffeinium hydrogen sulfate (CHS) as a green acid catalyst to afford various spiroxyindole derivatives via domino Knoevenagel‐Michael‐cyclization sequence. This environmentally benign protocol provides various advantages viz operational simplicity, excellent yield processing, cost‐effectiveness and short reaction time. High selectivity, broad substrate scope, recyclability of the catalyst and isolation of final products via simple filtration and recrystallization procedure are the prominent features of the presented methodology." @default.
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- W2917834013 date "2019-02-18" @default.
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- W2917834013 title "A Facile and Green Pathway for One-Pot Multicomponent Synthesis of Functionalized Spiroxyindoles using Caffeinium Hydrogen Sulfate as a Catalyst." @default.
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- W2917834013 doi "https://doi.org/10.1002/slct.201900121" @default.
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