Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917884512> ?p ?o ?g. }
- W2917884512 endingPage "98" @default.
- W2917884512 startingPage "89" @default.
- W2917884512 abstract "DNA damage response (DDR) serves as an integrated cellular network to detect cellular stress and react by activating pathways responsible for halting cell cycle progression, stimulating DNA damage repair, and initiating apoptosis. Efficient DDR protects cells from genomic instability while defective DDR can allow DNA lesions to go unrepaired, causing permanent mutations that will affect future generations of cells and possibly cause disease conditions such as cancer. Therefore, DDR mechanisms must be tightly regulated in order to ensure organismal health and viability. One major way of DDR regulation is ubiquitination, which has been long known to control DDR protein localization, activity, and stability. The reversal of this process, deubiquitination, has more recently come to the forefront of DDR research as an important new angle in ubiquitin-mediated regulation of DDR. As such, deubiquitinases have emerged as key factors in DDR. Importantly, deubiquitinases are attractive small-molecule drug targets due to their well-defined catalytic residues that provide a promising avenue for developing new cancer therapeutics. This review focuses on the emerging roles of deubiquitinases in various DNA repair pathways." @default.
- W2917884512 created "2019-03-02" @default.
- W2917884512 creator A5029636855 @default.
- W2917884512 creator A5046185800 @default.
- W2917884512 creator A5051480897 @default.
- W2917884512 creator A5076520986 @default.
- W2917884512 date "2019-04-01" @default.
- W2917884512 modified "2023-09-27" @default.
- W2917884512 title "Role of deubiquitinases in DNA damage response" @default.
- W2917884512 cites W1221688681 @default.
- W2917884512 cites W1482236046 @default.
- W2917884512 cites W1496600075 @default.
- W2917884512 cites W1552171878 @default.
- W2917884512 cites W1577743463 @default.
- W2917884512 cites W1823067028 @default.
- W2917884512 cites W1963967499 @default.
- W2917884512 cites W1968028576 @default.
- W2917884512 cites W1969503475 @default.
- W2917884512 cites W1970826261 @default.
- W2917884512 cites W1971792138 @default.
- W2917884512 cites W1972021276 @default.
- W2917884512 cites W1973904343 @default.
- W2917884512 cites W1976617402 @default.
- W2917884512 cites W1979338861 @default.
- W2917884512 cites W1979408355 @default.
- W2917884512 cites W1980745500 @default.
- W2917884512 cites W1982634724 @default.
- W2917884512 cites W1985786559 @default.
- W2917884512 cites W1990623204 @default.
- W2917884512 cites W1991249033 @default.
- W2917884512 cites W1995522994 @default.
- W2917884512 cites W1998499862 @default.
- W2917884512 cites W2000017794 @default.
- W2917884512 cites W2007277647 @default.
- W2917884512 cites W2008207745 @default.
- W2917884512 cites W2008744347 @default.
- W2917884512 cites W2012081711 @default.
- W2917884512 cites W2015031034 @default.
- W2917884512 cites W2021565943 @default.
- W2917884512 cites W2024707993 @default.
- W2917884512 cites W2025588303 @default.
- W2917884512 cites W2030475136 @default.
- W2917884512 cites W2032997281 @default.
- W2917884512 cites W2033055043 @default.
- W2917884512 cites W2042765650 @default.
- W2917884512 cites W2044856539 @default.
- W2917884512 cites W2045979076 @default.
- W2917884512 cites W2052779687 @default.
- W2917884512 cites W2058471321 @default.
- W2917884512 cites W2059763709 @default.
- W2917884512 cites W2060354742 @default.
- W2917884512 cites W2062520229 @default.
- W2917884512 cites W2065886319 @default.
- W2917884512 cites W2072355125 @default.
- W2917884512 cites W2073904860 @default.
- W2917884512 cites W2074536099 @default.
- W2917884512 cites W2075939050 @default.
- W2917884512 cites W2079076511 @default.
- W2917884512 cites W2081892455 @default.
- W2917884512 cites W2083903439 @default.
- W2917884512 cites W2083960841 @default.
- W2917884512 cites W2088504425 @default.
- W2917884512 cites W2088724822 @default.
- W2917884512 cites W2088794084 @default.
- W2917884512 cites W2089243923 @default.
- W2917884512 cites W2091364606 @default.
- W2917884512 cites W2092104135 @default.
- W2917884512 cites W2095424116 @default.
- W2917884512 cites W2096136751 @default.
- W2917884512 cites W2106571916 @default.
- W2917884512 cites W2108718931 @default.
- W2917884512 cites W2109511371 @default.
- W2917884512 cites W2113019206 @default.
- W2917884512 cites W2114907977 @default.
- W2917884512 cites W2116934683 @default.
- W2917884512 cites W2117546563 @default.
- W2917884512 cites W2121126196 @default.
- W2917884512 cites W2123241821 @default.
- W2917884512 cites W2124507445 @default.
- W2917884512 cites W212561335 @default.
- W2917884512 cites W2128114411 @default.
- W2917884512 cites W2130151956 @default.
- W2917884512 cites W2131676264 @default.
- W2917884512 cites W2133819225 @default.
- W2917884512 cites W2134071049 @default.
- W2917884512 cites W2139364069 @default.
- W2917884512 cites W2139592339 @default.
- W2917884512 cites W2141035944 @default.
- W2917884512 cites W2142795372 @default.
- W2917884512 cites W2147917253 @default.
- W2917884512 cites W2150123812 @default.
- W2917884512 cites W2156607330 @default.
- W2917884512 cites W2159928328 @default.
- W2917884512 cites W2160128169 @default.
- W2917884512 cites W2162223351 @default.
- W2917884512 cites W2163885210 @default.
- W2917884512 cites W2167844213 @default.
- W2917884512 cites W2175530476 @default.