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• W2917909266 abstract "Hair differs from other human materials used for toxicological analysis, such as bloodor urine, because of its substantially longer window of detection (months to years)enabling retrospective investigations of drug consumption. Due to its solid and durablenature, hair may be analysed centuries after growth with little degradation. Otheradvantages of hair analysis include the non-invasiveness of its collection, which is ofparticular importance in infant/child investigations and the ease of sample storage.Although hair analysis offers the potential to reveal information which is not possiblewith other biological matrices, it also suffers from some unique limitations that canmake interpretation of findings challenging. These are largely due to exposure of hairto the environment before analysis can take place.Current analytical techniques allow detection and quantification of cannabinoids inhair samples. Frequently used techniques include gas chromatography massspectrometry and liquid chromatography mass spectrometry. The majority of studiesexclusively analyse the natural products Δ9-tetrahydrocannabinol (THC), Cannabinol(CBN), cannabidiol (CBD) or the metabolite 11-nor-9-carboxy-tetrahydrocannabinol(THC-COOH).In this thesis THC, CBD, CBN, THC-COOH and the additional metabolite 11-Hydroxydelta-9-tetrahydrocannabinol (11-OH-THC) have been simultaneously detected andquantified in authentic hair samples using a novel atmospheric pressure chemicalionisation method coupled to gas chromatography mass spectrometry. The results ofthese findings are compared to self-report data and are largely found to be inconcordance, with some anomalies. In addition, several strategies to overcome thecomplication of external contamination of hair samples were trialled and compared toself-report data.In this thesis there is also an investigation presented to demonstrate the in-situderivatisation of cannabinoids using matrix-assisted laser desorption ionisation(MALDI). This is the first time a hair has been analysed for cannabinoids using MALDIand the first example of in situ derivatisation for hair samples.The addition of an N-methylpyridium group results in improved ionisation efficiency,permitting both detection and mapping of Δ9-tetrahydrocannabinol (THC), Cannabinol(CBN), cannabidiol (CBD) and the metabolites 11-nor-9-carboxy-tetrahydrocannabinol(THC-COOH), 11-Hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) and 11-nordelta(9)-carboxy-tetrahydrocannabinol glucuronide (THC-COO-gluc) in single hairsamples.Additionally, for the first time an in-source re-arrangement of THC is reported andcharacterised in this thesis, thus contributing new knowledge in the analysis of thisdrug by MALDI mass spectrometry." @default.
• W2917909266 created "2019-03-02" @default.
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• W2917909266 date "2019-02-27" @default.
• W2917909266 modified "2023-09-24" @default.
• W2917909266 title "Detection and Mapping of Cannabis Use in Hair Samples Using Mass Spectrometry" @default.
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• W2917909266 doi "https://doi.org/10.7190/shu-thesis-00142" @default.
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