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- W2917960056 abstract "The study addresses the association of marinobufagenin (MBG), a natriuretic and vasoconstrictor steroid, and Na/K-ATPase (NKA) activity with pressor response to salt-loading and arterial stiffness in resistant hypertension (RH). Thirty-four patients (18 males and 16 females; 56 ± 8 years) with RH on a combined (lisnopril/amlodipine/hydrochlorothiazide) therapy and 11 healthy age-matched normotensive subjects (7 males and 4 females; 54 ± 2 years) were enrolled in this study. Salt-loading was performed via intravenous infusion of 1000 mL saline (0.9% NaCl) for 1 h. Arterial stiffness was measured by Sphygmocor Px device with a calculation of pulse-wave velocity (PWV). Activity of NKA was measured in erythrocytes. We demonstrated that plasma levels of MBG and magnitude of NaCl-induced MBG-dependent NKA inhibition are associated with PWV, and that this association has gender- and age-specific fashion in RH patients." @default.
- W2917960056 created "2019-03-02" @default.
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- W2917960056 date "2019-01-01" @default.
- W2917960056 modified "2023-10-18" @default.
- W2917960056 title "Acute salt loading and cardiotonic steroids in resistant hypertension" @default.
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- W2917960056 doi "https://doi.org/10.1016/bs.ctm.2019.01.005" @default.
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