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• W2917963149 abstract "Aim: Hydralazine has led to the synthesis of phthalazinone derivatives which induce vasorelaxation. Methods: A new series of 2-(aminoalkyl)-4-benzyl-2H-phthalazin-1-one derivatives has been synthesized to study their vasorelaxant activity. Results: At the highest-studied concentration, most of the new compounds relaxed the denuded aortic rings precontracted with phenylephrine by 72.9–85.7%. Compound 25 (C25) suppressed almost totally the contractile effects of phenylephrine, high KCl concentration, ionomycin and caffeine related to the activation of Ca 2+ channels, whereas its inhibitory effect was reversed with high CaCl 2 concentrations. Conclusion: Vasodilator effects of C25 appear to be due exclusively to the reversible blockage of different calcium channels. As broad range calcium channel blocker, C25 seems to be suitable as a pharmacological tool for calcium channel research." @default.
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• W2917963149 date "2019-02-01" @default.
• W2917963149 modified "2023-09-23" @default.
• W2917963149 title "Discovery of new phthalazinones as vasodilator agents and novel pharmacological tools to study calcium channels" @default.
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• W2917963149 doi "https://doi.org/10.4155/fmc-2018-0250" @default.
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