FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917963199> ?p ?o ?g. }

• W2917963199 endingPage "697" @default.
• W2917963199 startingPage "691" @default.
• W2917963199 abstract "The mechanisms underlying aryl hydrocarbon receptor (AHR) activation by agonists and circumstances that increase the sensitivity toward agonists and AHR inhibition by antagonists are diverse and still not fully understood. AHR antagonist, 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide, CH223191, has been reported to inhibit the AHR transcription activity. However, CH223191 antagonist activity toward an AHR endogenous ligand, 6-formylindolo[3,2-b]carbazole (FICZ), and its mode of action remain to be elusive. Male BALB/c albino mice, HepG2 cells, and HepG2-XRE-Luc carrying cytochrome P4501A1 (CYP1A1) gene linked to a luciferase reporter were exposed to FICZ alone or in combination with CH223191, buthionine-(S,R)-sulfoximine (BSO), and N-acetyl-l-cysteine (NAC) for 5 h. Microsomal and cellular CYP1A1 enzyme activities, cellular FICZ levels, CYP1A1 reporter activity, mitochondrial membrane potential, and mitochondrial-dependent reactive oxygen species (ROS) formation were measured. In this study, we showed that AHR activity induced by an AHR endogenous ligand, FICZ, in a dose-dependent manner could be suppressed by CH223191. Indeed, we observed that CH223191 is able to inhibit the catalytic activity of CYP1A1, with an IC50 value of 1.48 μM. Our experiments with silencing RNA sequences showed that ROS formation by mitochondria might take part as a primary event in the downregulation of CYP1A1 by CH223191. We describe a new mechanism for inhibition of AHR-induced CYP1A1 by CH223191. The sensitivity of the AHR to oxidants and its possible reversibility by antioxidants supports the view that CH223191-induced mitochondrial dysfunction might be involved in this pharmacological event." @default.
• W2917963199 created "2019-03-02" @default.
• W2917963199 creator A5004972418 @default.
• W2917963199 creator A5028076833 @default.
• W2917963199 creator A5030958198 @default.
• W2917963199 date "2019-02-22" @default.
• W2917963199 modified "2023-10-06" @default.
• W2917963199 title "Impact of CH223191-Induced Mitochondrial Dysfunction on Its Aryl Hydrocarbon Receptor Agonistic and Antagonistic Activities" @default.
• W2917963199 cites W1541649582 @default.
• W2917963199 cites W1551348338 @default.
• W2917963199 cites W1907051965 @default.
• W2917963199 cites W1935479846 @default.
• W2917963199 cites W1935728713 @default.
• W2917963199 cites W1985754063 @default.
• W2917963199 cites W1997013077 @default.
• W2917963199 cites W2002062079 @default.
• W2917963199 cites W2011427930 @default.
• W2917963199 cites W2020792897 @default.
• W2917963199 cites W2040177546 @default.
• W2917963199 cites W2067835167 @default.
• W2917963199 cites W2072145718 @default.
• W2917963199 cites W2072729440 @default.
• W2917963199 cites W2077430334 @default.
• W2917963199 cites W2090939833 @default.
• W2917963199 cites W2107312924 @default.
• W2917963199 cites W2109440685 @default.
• W2917963199 cites W2112754168 @default.
• W2917963199 cites W2120406860 @default.
• W2917963199 cites W2124210208 @default.
• W2917963199 cites W2138913971 @default.
• W2917963199 cites W2142798058 @default.
• W2917963199 cites W2146957308 @default.
• W2917963199 cites W2151197941 @default.
• W2917963199 cites W2181543279 @default.
• W2917963199 cites W2262222944 @default.
• W2917963199 cites W2318366705 @default.
• W2917963199 cites W2336057597 @default.
• W2917963199 cites W2365176228 @default.
• W2917963199 cites W2596444461 @default.
• W2917963199 cites W2747391147 @default.
• W2917963199 cites W2769275919 @default.
• W2917963199 cites W2782774905 @default.
• W2917963199 cites W2783130112 @default.
• W2917963199 cites W2793980467 @default.
• W2917963199 cites W2891360658 @default.
• W2917963199 cites W94341715 @default.
• W2917963199 doi "https://doi.org/10.1021/acs.chemrestox.8b00371" @default.
• W2917963199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30793600" @default.
• W2917963199 hasPublicationYear "2019" @default.
• W2917963199 type Work @default.
• W2917963199 sameAs 2917963199 @default.
• W2917963199 citedByCount "16" @default.
• W2917963199 countsByYear W29179631992019 @default.
• W2917963199 countsByYear W29179631992020 @default.
• W2917963199 countsByYear W29179631992021 @default.
• W2917963199 countsByYear W29179631992022 @default.
• W2917963199 countsByYear W29179631992023 @default.
• W2917963199 crossrefType "journal-article" @default.
• W2917963199 hasAuthorship W2917963199A5004972418 @default.
• W2917963199 hasAuthorship W2917963199A5028076833 @default.
• W2917963199 hasAuthorship W2917963199A5030958198 @default.
• W2917963199 hasConcept C104317684 @default.
• W2917963199 hasConcept C170493617 @default.
• W2917963199 hasConcept C185592680 @default.
• W2917963199 hasConcept C202751555 @default.
• W2917963199 hasConcept C2776120743 @default.
• W2917963199 hasConcept C2776885963 @default.
• W2917963199 hasConcept C28859421 @default.
• W2917963199 hasConcept C33594762 @default.
• W2917963199 hasConcept C48349386 @default.
• W2917963199 hasConcept C55493867 @default.
• W2917963199 hasConcept C86339819 @default.
• W2917963199 hasConceptScore W2917963199C104317684 @default.
• W2917963199 hasConceptScore W2917963199C170493617 @default.
• W2917963199 hasConceptScore W2917963199C185592680 @default.
• W2917963199 hasConceptScore W2917963199C202751555 @default.
• W2917963199 hasConceptScore W2917963199C2776120743 @default.
• W2917963199 hasConceptScore W2917963199C2776885963 @default.
• W2917963199 hasConceptScore W2917963199C28859421 @default.
• W2917963199 hasConceptScore W2917963199C33594762 @default.
• W2917963199 hasConceptScore W2917963199C48349386 @default.
• W2917963199 hasConceptScore W2917963199C55493867 @default.
• W2917963199 hasConceptScore W2917963199C86339819 @default.
• W2917963199 hasFunder F4320322545 @default.
• W2917963199 hasIssue "4" @default.
• W2917963199 hasLocation W29179631991 @default.
• W2917963199 hasLocation W29179631992 @default.
• W2917963199 hasOpenAccess W2917963199 @default.
• W2917963199 hasPrimaryLocation W29179631991 @default.
• W2917963199 hasRelatedWork W1592173581 @default.
• W2917963199 hasRelatedWork W1982729063 @default.
• W2917963199 hasRelatedWork W1992225748 @default.
• W2917963199 hasRelatedWork W2033292825 @default.
• W2917963199 hasRelatedWork W2053022803 @default.
• W2917963199 hasRelatedWork W2111757377 @default.
• W2917963199 hasRelatedWork W2962947347 @default.
• W2917963199 hasRelatedWork W3184520397 @default.
• W2917963199 hasRelatedWork W3213309159 @default.

• next