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- W2917963413 endingPage "2034" @default.
- W2917963413 startingPage "2005" @default.
- W2917963413 abstract "Thyroid hormones are essential for brain maturation and function. Conditions associated with impaired action of thyroid hormones to the brain during development include iodine deficiency, maternal and fetal hypothyroidism, maternal hypothyroxinemia, prematurity, and mutations of thyroid hormone transporters and nuclear receptors. All these conditions may lead to various degrees of mental retardation and neurological impairment. This chapter is a review of the pathophysiology of thyroid hormone action in the brain. First, an analysis is made of the factors that control the tissue concentration and action of the active hormone triiodothyronine (T3), such as thyroidal secretion, tissue expression of deiodinases, cellular transporters, and nuclear receptors. This is followed by a survey of the genes regulated by thyroid hormone in brain and, finally, by a description of clinical situations caused by defective thyroid hormone signaling in an attempt to explain these syndromes with our present knowledge of thyroid hormone physiology and action at the molecular level." @default.
- W2917963413 created "2019-03-02" @default.
- W2917963413 creator A5042689915 @default.
- W2917963413 date "2009-01-01" @default.
- W2917963413 modified "2023-10-13" @default.
- W2917963413 title "Thyroid Hormones and Brain Development" @default.
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