Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917977606> ?p ?o ?g. }
- W2917977606 endingPage "10" @default.
- W2917977606 startingPage "1" @default.
- W2917977606 abstract "Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of nigral dopaminergic neurons innervating the striatum, the main input structure of the basal ganglia. This creates an imbalance between dopaminergic inputs and cholinergic interneurons (ChIs) within the striatum. The efficacy of anticholinergic drugs, one of the earliest therapy for PD before the discovery of L-3,4-dihydroxyphenylalanine (L-DOPA) suggests an increased cholinergic tone in this disease. The dopamine (DA)-acetylcholine (ACh) balance hypothesis is now revisited with the use of novel cutting-edge techniques (optogenetics, pharmacogenetics, new electrophysiological recordings). This review will provide the background of the specific contribution of ChIs to striatal microcircuit organization in physiological and pathological conditions. The second goal of this review is to delve into the respective contributions of nicotinic and muscarinic receptor cholinergic subunits to the control of striatal afferent and efferent neuronal systems. Special attention will be given to the role played by muscarinic acetylcholine receptors (mAChRs) in the regulation of striatal network which may have important implications in the development of novel therapeutic strategies for motor and cognitive impairment in PD." @default.
- W2917977606 created "2019-03-02" @default.
- W2917977606 creator A5001475191 @default.
- W2917977606 creator A5079379101 @default.
- W2917977606 date "2019-06-01" @default.
- W2917977606 modified "2023-10-13" @default.
- W2917977606 title "Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease" @default.
- W2917977606 cites W147935971 @default.
- W2917977606 cites W1487894289 @default.
- W2917977606 cites W1492689743 @default.
- W2917977606 cites W1548690558 @default.
- W2917977606 cites W1549437185 @default.
- W2917977606 cites W1555112731 @default.
- W2917977606 cites W1557320868 @default.
- W2917977606 cites W1571037251 @default.
- W2917977606 cites W1596886387 @default.
- W2917977606 cites W1598962518 @default.
- W2917977606 cites W1604729272 @default.
- W2917977606 cites W1622774380 @default.
- W2917977606 cites W1631089961 @default.
- W2917977606 cites W1717096433 @default.
- W2917977606 cites W1798722234 @default.
- W2917977606 cites W1885050361 @default.
- W2917977606 cites W1910271824 @default.
- W2917977606 cites W1969591714 @default.
- W2917977606 cites W1971982338 @default.
- W2917977606 cites W1975118796 @default.
- W2917977606 cites W1977546333 @default.
- W2917977606 cites W1978932203 @default.
- W2917977606 cites W197924405 @default.
- W2917977606 cites W1979928326 @default.
- W2917977606 cites W1982535961 @default.
- W2917977606 cites W1982827121 @default.
- W2917977606 cites W1982831931 @default.
- W2917977606 cites W1983885358 @default.
- W2917977606 cites W1985890505 @default.
- W2917977606 cites W1986210070 @default.
- W2917977606 cites W1987996701 @default.
- W2917977606 cites W1989236873 @default.
- W2917977606 cites W1989486566 @default.
- W2917977606 cites W1990162104 @default.
- W2917977606 cites W1991603311 @default.
- W2917977606 cites W1995931442 @default.
- W2917977606 cites W1997896450 @default.
- W2917977606 cites W1998152406 @default.
- W2917977606 cites W1998664518 @default.
- W2917977606 cites W1998777125 @default.
- W2917977606 cites W1999198024 @default.
- W2917977606 cites W1999774383 @default.
- W2917977606 cites W2001399983 @default.
- W2917977606 cites W2001415828 @default.
- W2917977606 cites W2002363647 @default.
- W2917977606 cites W2006457780 @default.
- W2917977606 cites W2006521913 @default.
- W2917977606 cites W2006866528 @default.
- W2917977606 cites W2006909079 @default.
- W2917977606 cites W2007836474 @default.
- W2917977606 cites W2008577993 @default.
- W2917977606 cites W2009002391 @default.
- W2917977606 cites W2011077714 @default.
- W2917977606 cites W2012019301 @default.
- W2917977606 cites W2012927321 @default.
- W2917977606 cites W2013141548 @default.
- W2917977606 cites W2014583604 @default.
- W2917977606 cites W2015040491 @default.
- W2917977606 cites W2017386708 @default.
- W2917977606 cites W2017426413 @default.
- W2917977606 cites W2018998508 @default.
- W2917977606 cites W2020762073 @default.
- W2917977606 cites W2022233762 @default.
- W2917977606 cites W2023374499 @default.
- W2917977606 cites W2023796931 @default.
- W2917977606 cites W2024831728 @default.
- W2917977606 cites W2025170140 @default.
- W2917977606 cites W2025449751 @default.
- W2917977606 cites W2025783691 @default.
- W2917977606 cites W2025936719 @default.
- W2917977606 cites W2026313063 @default.
- W2917977606 cites W2026866926 @default.
- W2917977606 cites W2027044265 @default.
- W2917977606 cites W2028725530 @default.
- W2917977606 cites W2031170958 @default.
- W2917977606 cites W2033904402 @default.
- W2917977606 cites W2034688331 @default.
- W2917977606 cites W2035599884 @default.
- W2917977606 cites W2036108975 @default.
- W2917977606 cites W2036216077 @default.
- W2917977606 cites W2036398723 @default.
- W2917977606 cites W2037741322 @default.
- W2917977606 cites W2039654930 @default.
- W2917977606 cites W2044687129 @default.
- W2917977606 cites W2046324408 @default.
- W2917977606 cites W2048779384 @default.
- W2917977606 cites W2049964614 @default.
- W2917977606 cites W2050688876 @default.
- W2917977606 cites W2052208553 @default.
- W2917977606 cites W2053868894 @default.
- W2917977606 cites W2055232873 @default.