FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918010247> ?p ?o ?g. }

• W2918010247 endingPage "1445" @default.
• W2918010247 startingPage "1439" @default.
• W2918010247 abstract "Liver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays a role in apoptosis induction. However, the precise impact of LKB1 expression on gastric cancer (GC) progression and its correlation with survivin and p53 in GC have not yet been elucidated.The aim of this study was to explore the significance of LKB1 expression and its correlation with p53 and survivin in GC.In this study, LKB1 expression was detected in GC and adjacent paracancerous tissues from 150 patients through immunohistochemical (IHC) staining. The relationship between LKB1 expression and clinical pathological factors in GC was analyzed, alongside its correlation with p53 and survivin expression.LKB1 expression was reduced in GC tissues compared with adjacent paracancerous tissues (P=0.001). In patients with GC, lower LKB1 expression was associated with greater invasion depth (P=0.013), higher pTNM stage (P=0.009), and lymph node metastasis (P=0.029). Furthermore, LKB1 expression in GC was inversely associated with p53 (r=-0.181, P=0.027) and survivin expression (r=-0.198, P=0.015). Kaplan-Meier analysis indicated that the expression of LKB1, p53 and survivin, as well as tumor differentiation, invasion, and pTNM and lymph node metastasis were all associated with overall survival (OS) (all P<0.05). Finally, multivariate analysis showed that LKB1 expression [hazard ratio (HR): 0.605 (0.414-0.882), P=0.009], p53 expression [hazard ratio (HR): 1.840 (1.232-2.750), P=0.003], and survivin expression [hazard ratio (HR): 1.561 (1.039-2.345), P=0.032] were all independent prognostic factors for patients with GC.Our study suggests that LKB1 expression is reduced in GC, negatively correlated with p53 and survivin expression, and plays an important role in predicting invasion and metastasis of GC." @default.
• W2918010247 created "2019-03-02" @default.
• W2918010247 creator A5050006992 @default.
• W2918010247 creator A5051009295 @default.
• W2918010247 creator A5053275663 @default.
• W2918010247 creator A5082529659 @default.
• W2918010247 date "2019-02-01" @default.
• W2918010247 modified "2023-10-18" @default.
• W2918010247 title "<p>Impact of liver kinase B1 on p53 and survivin and its correlation with prognosis in gastric cancer</p>" @default.
• W2918010247 cites W1601471013 @default.
• W2918010247 cites W1757407923 @default.
• W2918010247 cites W1975732800 @default.
• W2918010247 cites W2013718737 @default.
• W2918010247 cites W2028130050 @default.
• W2918010247 cites W2050178008 @default.
• W2918010247 cites W2050285623 @default.
• W2918010247 cites W2053134659 @default.
• W2918010247 cites W2067014460 @default.
• W2918010247 cites W2076132968 @default.
• W2918010247 cites W2082480920 @default.
• W2918010247 cites W2085076473 @default.
• W2918010247 cites W2098092858 @default.
• W2918010247 cites W2103571593 @default.
• W2918010247 cites W2123558789 @default.
• W2918010247 cites W2133348184 @default.
• W2918010247 cites W2168249970 @default.
• W2918010247 cites W2272984102 @default.
• W2918010247 cites W2302195414 @default.
• W2918010247 cites W2438865322 @default.
• W2918010247 cites W2888848619 @default.
• W2918010247 cites W4248779953 @default.
• W2918010247 doi "https://doi.org/10.2147/ott.s199138" @default.
• W2918010247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6390856" @default.
• W2918010247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30863111" @default.
• W2918010247 hasPublicationYear "2019" @default.
• W2918010247 type Work @default.
• W2918010247 sameAs 2918010247 @default.
• W2918010247 citedByCount "5" @default.
• W2918010247 countsByYear W29180102472019 @default.
• W2918010247 countsByYear W29180102472020 @default.
• W2918010247 countsByYear W29180102472022 @default.
• W2918010247 countsByYear W29180102472023 @default.
• W2918010247 crossrefType "journal-article" @default.
• W2918010247 hasAuthorship W2918010247A5050006992 @default.
• W2918010247 hasAuthorship W2918010247A5051009295 @default.
• W2918010247 hasAuthorship W2918010247A5053275663 @default.
• W2918010247 hasAuthorship W2918010247A5082529659 @default.
• W2918010247 hasBestOaLocation W29180102471 @default.
• W2918010247 hasConcept C121608353 @default.
• W2918010247 hasConcept C126322002 @default.
• W2918010247 hasConcept C142724271 @default.
• W2918010247 hasConcept C143998085 @default.
• W2918010247 hasConcept C190283241 @default.
• W2918010247 hasConcept C204232928 @default.
• W2918010247 hasConcept C207103383 @default.
• W2918010247 hasConcept C207886595 @default.
• W2918010247 hasConcept C2775975398 @default.
• W2918010247 hasConcept C2779013556 @default.
• W2918010247 hasConcept C44249647 @default.
• W2918010247 hasConcept C502942594 @default.
• W2918010247 hasConcept C50382708 @default.
• W2918010247 hasConcept C55493867 @default.
• W2918010247 hasConcept C71924100 @default.
• W2918010247 hasConcept C86803240 @default.
• W2918010247 hasConceptScore W2918010247C121608353 @default.
• W2918010247 hasConceptScore W2918010247C126322002 @default.
• W2918010247 hasConceptScore W2918010247C142724271 @default.
• W2918010247 hasConceptScore W2918010247C143998085 @default.
• W2918010247 hasConceptScore W2918010247C190283241 @default.
• W2918010247 hasConceptScore W2918010247C204232928 @default.
• W2918010247 hasConceptScore W2918010247C207103383 @default.
• W2918010247 hasConceptScore W2918010247C207886595 @default.
• W2918010247 hasConceptScore W2918010247C2775975398 @default.
• W2918010247 hasConceptScore W2918010247C2779013556 @default.
• W2918010247 hasConceptScore W2918010247C44249647 @default.
• W2918010247 hasConceptScore W2918010247C502942594 @default.
• W2918010247 hasConceptScore W2918010247C50382708 @default.
• W2918010247 hasConceptScore W2918010247C55493867 @default.
• W2918010247 hasConceptScore W2918010247C71924100 @default.
• W2918010247 hasConceptScore W2918010247C86803240 @default.
• W2918010247 hasLocation W29180102471 @default.
• W2918010247 hasLocation W29180102472 @default.
• W2918010247 hasLocation W29180102473 @default.
• W2918010247 hasLocation W29180102474 @default.
• W2918010247 hasOpenAccess W2918010247 @default.
• W2918010247 hasPrimaryLocation W29180102471 @default.
• W2918010247 hasRelatedWork W2388731891 @default.
• W2918010247 hasRelatedWork W2521562244 @default.
• W2918010247 hasRelatedWork W2580481553 @default.
• W2918010247 hasRelatedWork W2994686985 @default.
• W2918010247 hasRelatedWork W3032354441 @default.
• W2918010247 hasRelatedWork W3151141465 @default.
• W2918010247 hasRelatedWork W3171350128 @default.
• W2918010247 hasRelatedWork W4254004086 @default.
• W2918010247 hasRelatedWork W4281722959 @default.
• W2918010247 hasRelatedWork W4379796428 @default.
• W2918010247 hasVolume "Volume 12" @default.
• W2918010247 isParatext "false" @default.

• next