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- W2918043959 abstract "Aim: MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit sKlotho. This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho. Methods: The expression of miR-335-5p was detected in human umbilical vein endothelial cells treated with H2O2. Subsequently, endothelial function and sKlotho expression were measured in human umbilical vein endothelial cells treated with H2O2 and transfected with miR-335-5p mimics or inhibitor sequences. Vector containing reporting system of sKlotho3'- untranslated region with a miR-335-5p-binding site was constructed. Results: H2O2 stimulation significantly increased miR-335-5p expression. Force overexpression miR-335-5p suppress ECs function and sKlotho expression. MiR-335-5p target regulated sKlotho. Conclusion: MiR-335-5p might serve as a negative factor for endothelial homeostasis and a potential treatment target for atherosclerosis." @default.
- W2918043959 created "2019-03-02" @default.
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- W2918043959 date "2019-04-01" @default.
- W2918043959 modified "2023-10-18" @default.
- W2918043959 title "Micro-RNA335-5p targeted inhibition of <i>sKlotho</i> and promoted oxidative stress–mediated aging of endothelial cells" @default.
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- W2918043959 doi "https://doi.org/10.2217/bmm-2018-0430" @default.
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