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- W2918069602 abstract "Background . The search for new markers of the epileptogenic zone (EZ) for the surgical treatment of epilepsy is currently of relevance. Pathological high-frequency oscillations (pHFO) are considered to be a potential marker for EZ. Papers devoted to this topic are few and insufficiently systematized, mostly due to a small quantity of patients. Objective . This study was aimed to determine the diagnostic efficacy of high-frequency electrocorticography (HF ECoG) based on the epilepsy surgery outcomes. Design and methods . This is an original retrospective study of high-frequency bioelectrical activity parameters in 114 patients who underwent surgical treatment in the Polenov Neurosurgical Institute Clinic during 2017–2018. In the subgroup of patients with pharmacoresistant course of structural epilepsy (21 patients) on the preresective electrocorticogram, the pHFO index was higher than in the subgroup with intracerebral neoplasms (11 patients), which may be associated with a longer history and severity of the disease. Results . Through the analysis of the high-frequency component of the post-resective HF ECoG, it was shown that the presence or absence of pHFO in the range of 250–500 Hz does not affect the seizure outcome. The dynamics of the high-frequency activity index before and after the resection are statistically significant for the seizure outcome prediction for structural epilepsy surgery. In this study, the specificity of the pHFO dynamics analysis technique was 85.71 % and sensitivity equaled 58.33 %. Conclusion . Thus, the HF ECoG and the assessment of the dynamics of the pHFO index in the range of 250–500 Hz can complement the traditional method of intraoperative ECoG in the range of up to 70 Hz, including the prediction of the results of surgical treatment." @default.
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- W2918069602 date "2019-02-21" @default.
- W2918069602 modified "2023-09-27" @default.
- W2918069602 title "HIGH-FREQUENCY ELECTROCORTICOGRAPHIC MARKER OF EPILEPTOGENIC ZONE" @default.
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- W2918069602 doi "https://doi.org/10.18705/2311-4495-2018-5-6-23-30" @default.
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