FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918089991> ?p ?o ?g. }

• W2918089991 endingPage "595" @default.
• W2918089991 startingPage "587" @default.
• W2918089991 abstract "The objective of the current study was to explore the efficacy of using pH-weighted amine CEST-EPI as a potential non-invasive imaging biomarker for treatment response and/or failure in recurrent GBM patients treated with bevacizumab.A total of 11 patients with recurrent GBM treated with bevacizumab were included in this prospective study. CEST-EPI, perfusion MRI, and standardized anatomic MRI were obtained in patients before and after bevacizumab administration. CEST-EPI measures of magnetization transfer ratio asymmetry (MTRasym) at 3 ppm were used for pH-weighted imaging contrast. Multiple measures were examined for their association with progression-free survival (PFS).Tumor acidity, measured with MTRasym at 3 ppm, was significantly reduced in both contrast enhancing and non-enhancing tumor after bevacizumab (p = 0.0002 and p < 0.00001, respectively). The reduction in tumor acidity in both contrast enhancing and non-enhancing tumor was linearly correlated with PFS (p = 0.044 and p = 0.00026, respectively). In 9 of the 11 patients, areas of residual acidity were localized to areas of tumor recurrence, typically around 2 months prior to radiographic progression. Univariate (p = 0.006) and multivariate Cox regression controlling for age (p = 0.009) both indicated that change in tumor acidity (ΔMTRasym at 3 ppm) was a significant predictor of PFS.This pilot study suggests pH-weighted amine CEST MRI may have value as a non-invasive, early imaging biomarker for bevacizumab treatment response and failure. Early decreases MTRasym at 3.0 ppm in recurrent GBM after bevacizumab may be associated with better PFS. Residual or emerging regions of acidity may colocalize to the site of tumor recurrence." @default.
• W2918089991 created "2019-03-02" @default.
• W2918089991 creator A5016476909 @default.
• W2918089991 creator A5017671349 @default.
• W2918089991 creator A5024208131 @default.
• W2918089991 creator A5025351354 @default.
• W2918089991 creator A5025556377 @default.
• W2918089991 creator A5030410351 @default.
• W2918089991 creator A5038569402 @default.
• W2918089991 creator A5046758575 @default.
• W2918089991 creator A5057258539 @default.
• W2918089991 creator A5063511816 @default.
• W2918089991 creator A5067837083 @default.
• W2918089991 creator A5078400193 @default.
• W2918089991 creator A5084168615 @default.
• W2918089991 date "2019-02-26" @default.
• W2918089991 modified "2023-10-14" @default.
• W2918089991 title "pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) as a potential early biomarker for bevacizumab failure in recurrent glioblastoma" @default.
• W2918089991 cites W1778792884 @default.
• W2918089991 cites W1911361012 @default.
• W2918089991 cites W1970855001 @default.
• W2918089991 cites W1976578289 @default.
• W2918089991 cites W1985336971 @default.
• W2918089991 cites W2006202974 @default.
• W2918089991 cites W2028437938 @default.
• W2918089991 cites W2048848878 @default.
• W2918089991 cites W2052110007 @default.
• W2918089991 cites W2069973979 @default.
• W2918089991 cites W2096287682 @default.
• W2918089991 cites W2100313731 @default.
• W2918089991 cites W2115749410 @default.
• W2918089991 cites W2123021957 @default.
• W2918089991 cites W2125053937 @default.
• W2918089991 cites W2131714579 @default.
• W2918089991 cites W2137261274 @default.
• W2918089991 cites W2140704845 @default.
• W2918089991 cites W2148977460 @default.
• W2918089991 cites W2156330848 @default.
• W2918089991 cites W2162643152 @default.
• W2918089991 cites W2166921825 @default.
• W2918089991 cites W2301275595 @default.
• W2918089991 cites W2326523632 @default.
• W2918089991 cites W2366536035 @default.
• W2918089991 cites W2507390322 @default.
• W2918089991 cites W2523123787 @default.
• W2918089991 cites W2796147996 @default.
• W2918089991 cites W2809272344 @default.
• W2918089991 cites W2899185085 @default.
• W2918089991 cites W4234865248 @default.
• W2918089991 doi "https://doi.org/10.1007/s11060-019-03132-z" @default.
• W2918089991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6482078" @default.
• W2918089991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30806888" @default.
• W2918089991 hasPublicationYear "2019" @default.
• W2918089991 type Work @default.
• W2918089991 sameAs 2918089991 @default.
• W2918089991 citedByCount "25" @default.
• W2918089991 countsByYear W29180899912020 @default.
• W2918089991 countsByYear W29180899912021 @default.
• W2918089991 countsByYear W29180899912022 @default.
• W2918089991 countsByYear W29180899912023 @default.
• W2918089991 crossrefType "journal-article" @default.
• W2918089991 hasAuthorship W2918089991A5016476909 @default.
• W2918089991 hasAuthorship W2918089991A5017671349 @default.
• W2918089991 hasAuthorship W2918089991A5024208131 @default.
• W2918089991 hasAuthorship W2918089991A5025351354 @default.
• W2918089991 hasAuthorship W2918089991A5025556377 @default.
• W2918089991 hasAuthorship W2918089991A5030410351 @default.
• W2918089991 hasAuthorship W2918089991A5038569402 @default.
• W2918089991 hasAuthorship W2918089991A5046758575 @default.
• W2918089991 hasAuthorship W2918089991A5057258539 @default.
• W2918089991 hasAuthorship W2918089991A5063511816 @default.
• W2918089991 hasAuthorship W2918089991A5067837083 @default.
• W2918089991 hasAuthorship W2918089991A5078400193 @default.
• W2918089991 hasAuthorship W2918089991A5084168615 @default.
• W2918089991 hasBestOaLocation W29180899912 @default.
• W2918089991 hasConcept C126322002 @default.
• W2918089991 hasConcept C126838900 @default.
• W2918089991 hasConcept C143409427 @default.
• W2918089991 hasConcept C185592680 @default.
• W2918089991 hasConcept C2776694085 @default.
• W2918089991 hasConcept C2777802072 @default.
• W2918089991 hasConcept C2778227246 @default.
• W2918089991 hasConcept C2781197716 @default.
• W2918089991 hasConcept C27826641 @default.
• W2918089991 hasConcept C2989005 @default.
• W2918089991 hasConcept C45664433 @default.
• W2918089991 hasConcept C502942594 @default.
• W2918089991 hasConcept C55493867 @default.
• W2918089991 hasConcept C71924100 @default.
• W2918089991 hasConceptScore W2918089991C126322002 @default.
• W2918089991 hasConceptScore W2918089991C126838900 @default.
• W2918089991 hasConceptScore W2918089991C143409427 @default.
• W2918089991 hasConceptScore W2918089991C185592680 @default.
• W2918089991 hasConceptScore W2918089991C2776694085 @default.
• W2918089991 hasConceptScore W2918089991C2777802072 @default.
• W2918089991 hasConceptScore W2918089991C2778227246 @default.
• W2918089991 hasConceptScore W2918089991C2781197716 @default.
• W2918089991 hasConceptScore W2918089991C27826641 @default.

• next