FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918112930> ?p ?o ?g. }

• W2918112930 abstract "Mast cells are primary players in immune and inflammatory diseases. In the brain, mast cells are located at the brain side of the blood brain barrier (BBB) exerting a crucial role in protecting the brain from xenobiotic invasion. Furthermore, recent advances in neuroscience indicate mast cells may play an important role in glial cell-neuron communication through the release of mediators, including histamine. Interestingly, brain mast cells contain 50% of the brain histamine but also hormones, proteases and lipids or amine mediators and cell degranulation may be triggered by different stimuli activating membrane bound receptors including the four types of histaminergic receptors. Among hormones, mast cells can store thyroid hormone (T3) and express membrane-bound TSH receptors, thus suggesting from one side that thyroid function may affect mast cells function, from the other that mast cell degranulation may impact on thyroid function. In this respect , the research on hormones in mast cells is scarcely. Recent pharmacological evidence indicates the existence of a non-genomic portion of the thyroid secretion including thyroid hormone metabolites. Among which the 2,3,didiodothyronine (3,5T2), 3-iodothyroanamine (T1AM) and 3-iodothryoacetic acid (TA1) are the most studied. All these compounds are endogenously occurring and found increased in inflammatory-based diseases involving mast cells. T1AM and TA1 induce, as T3, neuroprotective effects and itch but also hyperalgesia in rodents with a mechanism largely unknown but mediated by the release of histamine . Due to the rapid onset of their effectiveness they may trigger histamine release from a cell where it is “ready-to-be released”, i.e. mast cells. Following a very thin path which passes through old experimental and clinical evidence, at the light of novel acquisitions on endogenous T3 metabolites, we aim to stimulate the attention on the possibility that mast cell histamine may be the connector of a novel (neuro)endocrine pathway linking the thyroid with mast cells." @default.
• W2918112930 created "2019-03-02" @default.
• W2918112930 creator A5006014297 @default.
• W2918112930 creator A5013507539 @default.
• W2918112930 creator A5029498080 @default.
• W2918112930 creator A5041901658 @default.
• W2918112930 creator A5066204941 @default.
• W2918112930 date "2019-03-29" @default.
• W2918112930 modified "2023-09-29" @default.
• W2918112930 title "Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue" @default.
• W2918112930 cites W1054490 @default.
• W2918112930 cites W117956676 @default.
• W2918112930 cites W1486435744 @default.
• W2918112930 cites W1549899718 @default.
• W2918112930 cites W1553329582 @default.
• W2918112930 cites W1602307529 @default.
• W2918112930 cites W1739247397 @default.
• W2918112930 cites W18091031 @default.
• W2918112930 cites W1918372060 @default.
• W2918112930 cites W1965559613 @default.
• W2918112930 cites W1966657043 @default.
• W2918112930 cites W1969728966 @default.
• W2918112930 cites W1979576102 @default.
• W2918112930 cites W1980610279 @default.
• W2918112930 cites W1982792932 @default.
• W2918112930 cites W1998244259 @default.
• W2918112930 cites W1999610793 @default.
• W2918112930 cites W2001497964 @default.
• W2918112930 cites W2003200425 @default.
• W2918112930 cites W2011592796 @default.
• W2918112930 cites W2019807346 @default.
• W2918112930 cites W2019882992 @default.
• W2918112930 cites W2021237871 @default.
• W2918112930 cites W2023425111 @default.
• W2918112930 cites W2024180086 @default.
• W2918112930 cites W2028399387 @default.
• W2918112930 cites W2033170242 @default.
• W2918112930 cites W2047289730 @default.
• W2918112930 cites W2052397552 @default.
• W2918112930 cites W2058755346 @default.
• W2918112930 cites W2064793643 @default.
• W2918112930 cites W2068056383 @default.
• W2918112930 cites W2070651830 @default.
• W2918112930 cites W2071561102 @default.
• W2918112930 cites W2077790704 @default.
• W2918112930 cites W2078177376 @default.
• W2918112930 cites W2089923810 @default.
• W2918112930 cites W2114867773 @default.
• W2918112930 cites W2119563039 @default.
• W2918112930 cites W2119827901 @default.
• W2918112930 cites W2121166157 @default.
• W2918112930 cites W2121588417 @default.
• W2918112930 cites W2127263019 @default.
• W2918112930 cites W2150138603 @default.
• W2918112930 cites W2156536410 @default.
• W2918112930 cites W2186295141 @default.
• W2918112930 cites W2272647845 @default.
• W2918112930 cites W2467009591 @default.
• W2918112930 cites W2737457605 @default.
• W2918112930 cites W2767080260 @default.
• W2918112930 cites W2772942926 @default.
• W2918112930 cites W2776905669 @default.
• W2918112930 cites W2788501912 @default.
• W2918112930 cites W2790569773 @default.
• W2918112930 cites W2799273224 @default.
• W2918112930 cites W2804060265 @default.
• W2918112930 cites W2804849069 @default.
• W2918112930 cites W2883811740 @default.
• W2918112930 cites W2887592114 @default.
• W2918112930 cites W2888563137 @default.
• W2918112930 cites W2899004524 @default.
• W2918112930 cites W2904498275 @default.
• W2918112930 cites W4253477238 @default.
• W2918112930 cites W60045440 @default.
• W2918112930 doi "https://doi.org/10.3389/fncel.2019.00079" @default.
• W2918112930 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6449760" @default.
• W2918112930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30983971" @default.
• W2918112930 hasPublicationYear "2019" @default.
• W2918112930 type Work @default.
• W2918112930 sameAs 2918112930 @default.
• W2918112930 citedByCount "18" @default.
• W2918112930 countsByYear W29181129302019 @default.
• W2918112930 countsByYear W29181129302020 @default.
• W2918112930 countsByYear W29181129302021 @default.
• W2918112930 countsByYear W29181129302022 @default.
• W2918112930 countsByYear W29181129302023 @default.
• W2918112930 crossrefType "journal-article" @default.
• W2918112930 hasAuthorship W2918112930A5006014297 @default.
• W2918112930 hasAuthorship W2918112930A5013507539 @default.
• W2918112930 hasAuthorship W2918112930A5029498080 @default.
• W2918112930 hasAuthorship W2918112930A5041901658 @default.
• W2918112930 hasAuthorship W2918112930A5066204941 @default.
• W2918112930 hasBestOaLocation W29181129301 @default.
• W2918112930 hasConcept C109115496 @default.
• W2918112930 hasConcept C1122143 @default.
• W2918112930 hasConcept C126322002 @default.
• W2918112930 hasConcept C134018914 @default.
• W2918112930 hasConcept C170493617 @default.
• W2918112930 hasConcept C185592680 @default.
• W2918112930 hasConcept C203014093 @default.

• next