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- W2918182323 abstract "Photo-controlled affinity reagents seek to provide modular spatiotemporal control of bioactivity by conferring photo-switchability of function on an affinity reagent scaffold. Here we used Rosetta-based computational methods to screen for sites on the Fynomer affinity reagent structure for attachment of photoswitchable cross-linkers. Both established UV-based cross-linkers (azobenzene-iodoacetamide (IAC)) and an azonium-based efficient red light switchable cross-linker, piperazino-tetra-ortho-methoxy azobenzene (PIP), were then tested experimentally. Several sites compatible with Fynomer function were identified, including sites showing rapid (<10s) red light (633 nm) modulation of function. While a range of overall target binding affinities were observed, the degree of photo-switchability of Fynomer function was generally small (<2-fold). Computational models suggest that local flexibility limits the degree of switching seen in these designs." @default.
- W2918182323 created "2019-03-11" @default.
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- W2918182323 date "2019-03-28" @default.
- W2918182323 modified "2023-10-13" @default.
- W2918182323 title "Photoswitchable Affinity Reagents: Computational Design and Efficient Red‐Light Switching" @default.
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- W2918182323 doi "https://doi.org/10.1002/cptc.201900016" @default.
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