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- W2918182843 abstract "Surgical adhesives are an attractive alternative to traditional mechanical tissue fixation methods of sutures and staples. Ease of application, biocompatibility, enhanced functionality (drug delivery) are known advantages but weak adhesion strength in the wet environment and lack of tissue compliant behavior still pose a challenge. In order to address these issues, non-aqueous bioadhesive based on blends of polyamidoamine (PAMAM) dendrimer, conjugated with 4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzyl bromide (PAMAM-g-diazirine) and liquid polyethylene glycol (PEG 400) has been developed. PEG 400 biocompatible solvent reduces the viscosity of PAMAM-g-diazirine dendrimer without incorporating aqueous solvents or plasticizers, allowing application by syringe or spray. Upon UV activation, diazirine-generated reactive intermediates lead to intermolecular dendrimer crosslinking. The properties of the crosslinked matrix are tissue compliant, with anisotropic material properties dependent on the PEG 400 wt%, UV dose, pressure and uncured adhesive thickness. The hygroscopic PAMAM-g-diazirine/PEG 400 blend was hypothesized to absorb water at the tissue interface, leading to high interfacial adhesion, however porous matrices led to cohesive failure. The hydrophilic nature of the polyether backbone (PEG 400) shielded cationic PAMAM dendrimers with cured bioadhesive film displaying significantly less platelet activation than neat PAMAM-g-diazirine or PLGA thin films." @default.
- W2918182843 created "2019-03-11" @default.
- W2918182843 creator A5025769182 @default.
- W2918182843 creator A5047138699 @default.
- W2918182843 creator A5057944623 @default.
- W2918182843 creator A5073939882 @default.
- W2918182843 date "2019-07-01" @default.
- W2918182843 modified "2023-10-12" @default.
- W2918182843 title "Non-aqueous, tissue compliant carbene-crosslinking bioadhesives" @default.
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- W2918182843 doi "https://doi.org/10.1016/j.msec.2019.03.001" @default.
- W2918182843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30948055" @default.
- W2918182843 hasPublicationYear "2019" @default.
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