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• W2918184466 abstract "Drug repurposing has become an integral part of anti-infective discovery programs. Lack of newer antibiotics, emergence of the drug-resistant strains of the pathogens, unmet medical needs, and exceptionally longer development time for newer anti-infectives, have contributed significantly in the anti-infectives drug repurposing campaigns. Several computational approaches such as systems biology, computer-aided molecular design, network-based methods, etc., have generated meaningful repurposing hypothesis that were validated experimentally. The current chapter discusses drug-repurposing investigations, with a particular emphasis on the computational aspects, against bacterial (Gram-positive, Gram-negative, and Mycobacterium tuberculosis), viral, antiparasitic (with particular emphasis on neglected tropical diseases, NTDs), and fungal infections over the last 3–5 years. The issues related to the drug repurposing, such as intellectual property, off-label, or unknown potential use in the clinic and regulatory agencies, are briefly touched upon towards the end of the chapter. Several reported studies urge the experimentalists to undertake further evaluation of the potentially useful to-be-repurposed-soon drugs in therapeutic areas with unmet medical need. The concept seems simple but the applications are not straightforward. Thorough understanding of the limitations of the technique and the issues at hand are likely to expand the applicability domain of the drug-repurposing methodologies." @default.
• W2918184466 created "2019-03-11" @default.
• W2918184466 creator A5020453559 @default.
• W2918184466 creator A5068680457 @default.
• W2918184466 creator A5069312240 @default.
• W2918184466 creator A5072357866 @default.
• W2918184466 date "2019-01-01" @default.
• W2918184466 modified "2023-09-25" @default.
• W2918184466 title "Drug Repurposing in Search of Anti-Infectives: Need of the Hour in the Multidrug Resistance Era!" @default.
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