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• W2918213720 endingPage "E1060" @default.
• W2918213720 startingPage "E1050" @default.
• W2918213720 abstract "Diabetic retinopathy (DR) is a serious diabetic complication caused by both environmental and genetic factors. Molecular mechanisms of DR may lead to the discovery of reliable prognostic indicators. The current study aimed to clarify the mechanism of microRNA-183 (miR-183) in DR in relation to the PI3K/Akt/VEGF signaling pathway. Microarray-based gene expression profiling of DR was used to identify the differentially expressed genes. Sprague-Dawley rats were used for the establishment of DR models, and then miR-183 was altered by mimic or inhibitor or BTG1 was downregulated by siRNA to explore the regulatory mechanism of miR-183 in DR. Furthermore, the expression of miR-183, CD34, endothelial nitric oxide synthase (eNOS), BTG1 and the PI3K/Akt/VEGF signaling pathway-related genes as well as reactive oxygen species (ROS) level was determined, and the relationship between miR-183 and BTG1 was also verified. Cell growth, cell apoptosis, and angiogenesis were determined. Microarray analysis revealed the involvement of miR-183 in DR via the PI3K/Akt/VEGF signaling pathway by targeting BTG1. Upregulated miR-183 and downregulated BTG1 were observed in retinal tissues of DR rats. miR-183 overexpression activated the PI3K/Akt/VEGF signaling pathway, upregulated CD34, eNOS, and ROS, and inhibited BTG1. BTG1 was confirmed as a target gene of miR-183. miR-183 overexpression or BTG1 knockdown promoted cell growth and tube formation while it suppressed cell apoptosis of vascular endothelial cells in DR rats. In this study, we demonstrated that miR-183 silencing inhibiting cell growth and tube formation in vascular endothelial cells of DR rats via the PI3K/Akt/VEGF signaling pathway by upregulating BTG1." @default.
• W2918213720 created "2019-03-11" @default.
• W2918213720 creator A5017947172 @default.
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• W2918213720 date "2019-06-01" @default.
• W2918213720 modified "2023-10-06" @default.
• W2918213720 title "MicroRNA-183 inhibition exerts suppressive effects on diabetic retinopathy by inactivating <i>BTG1</i>-mediated PI3K/Akt/VEGF signaling pathway" @default.
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• W2918213720 doi "https://doi.org/10.1152/ajpendo.00444.2018" @default.
• W2918213720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30835506" @default.
• W2918213720 hasPublicationYear "2019" @default.
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