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- W29182208 abstract "Cancer of respiratory tract is among the most common neoplasms in the U.S and European countries but etiology and mechanisms of neoplastic transformation are not understood. Different types of respiratory tract lesions including squamous metaplasia, squamous cell carcinoma and adenocarcinoma have been described. Since the respiratory tract contains different epithelia i.e. mucosal epithelium and submucosal glands, it is possible that various lesions have different cell types of origin. Much effort has been devoted to the study of tracheal and bronchial mucosal cells which have been successfully cultured and neoplastically transformed (1–3). The untransformed and transformed cells in vitro however, lose their inherent property of mucus secretion. Submucosal glands in human trachea constitute the major tissue contributing to respiratory mucus and may also constitute the cell of origin of respiratory adenocarcinoma. We have propagated in serum-free medium, mucin producing epithelial cells from the human tracheal glands (4). The cell cultures however, undergo senescence after few passages precluding studies on biochemical and molecular mechanisms of growth and differentiation which require large numbers of cells. We have transformed the human tracheal gland epithelial (HTGE) cells by infection with adenovirus 12-SV40 hybrid virus (Ad 12-SV40)." @default.
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- W29182208 date "1991-01-01" @default.
- W29182208 modified "2023-09-24" @default.
- W29182208 title "Transformation of Human Tracheal Gland Epithelial Cells in vitro" @default.
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- W29182208 doi "https://doi.org/10.1007/978-1-4612-0411-4_33" @default.
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