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- W2918249314 abstract "ABSTRACTIntroduction: Congenital leukemia is definedas leukemia that develops intra uterine. Itis an extremely rare malignancy associatedwith poor prognosis and a poorly understoodnatural history. Incidence reported to be 1 per-5million neonates. Acute myeloblastic leukemiais more common than acute lymphoblasticleukemia in neonate. Clinical signs of neonatalleukemia among various patients such ashepatosplenomegaly, enlarged lymph nodes,leukemia cutis, and hyperleukocytosis. CaseReport: We present a 6-days-old female neonate,referred to Sanglah Hospital with respiratorydistress and lethargy. We found her with highbreathing effort and fever. Physical examinationfound hepatomegaly. Laboratory examinationsshowed hyperleukocytosis (leucocyte count140.000/mm3), anemia (hemoglobin 12.56 g/dL), normal thrombocytes count (245.400/mm3), and other laboratories within normallimits. Peripheral blood smear showederythrocyte with normocytic normochromic,normoblastemia, leucocytes with elevatedwhite blood cell count, immature white bloodcells (blasts) as appeared in acute leukemia.Leukemia phenotyping showed myeloid lineagewith aberrant expression CD 7 appropriate toacute myeloblastic leukemia. We diagnosedthe patient with acute myeloblastic leukemia.Patient got hydration intravenously in orderto prevent leukostasis syndrome. We plannedBagus Ngurah Mahakrishna1, Ketut Ariawati1Affiliation: 1Department of Child Health, Faculty of Medicine,Udayana University/Sanglah Hospital, Denpasar-Bali.Corresponding Author: Bagus Ngurah Mahakrishna, Denpasar-Bali-Indonesia; Email: bagusngurahmahakrishna@yahoo.comReceived: 08 June 2018Accepted: 06 August 2018Published: 29 August 2018PEER REVIEWED | OPEN ACCESSa chemotherapy protocol. Conclusion: Acutemyeloblastic leukemia in neonate is a rarecase. It was fetal form of malignant diseaseswith various clinical presentation such as highbreathing effort and hyperleukocytosis. Its exactcause is still not fully understood. Congenitalleukemia has a poor prognosis with an overallsurvival rate only 20% at 2 years of age.Keywords: Acute myeloblastic leukemia, Hyperleukocytosis,Malignancy, Neonate" @default.
- W2918249314 created "2019-03-11" @default.
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- W2918249314 date "2020-07-02" @default.
- W2918249314 modified "2023-09-27" @default.
- W2918249314 title "Acute myeloblastic leukemia in neonate" @default.
- W2918249314 doi "https://doi.org/10.5348/100004z19bm2018cr" @default.
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