Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918384611> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2918384611 abstract "Author(s): Yu, Olivia | Advisor(s): Heller Brown, Joan | Abstract: The ability of a subset of G-protein coupled receptors (GPCRs) to activate RhoAendows them with unique growth regulatory properties. Dysregulation of steps in thissignaling process subvert the normal control of RhoA activation and may underlie pathophysiological changes in gene expression and downstream responses such as glioblastoma tumor cell growth or fibrosis. Chapter 1 serves as an introduction to this thesis and provides background information on our current understanding of RhoA signaling and transcriptional responses. Chapter 2 describes the protein cysteine-rich angiogenic inducer 61 (CCN1) as a downstream target gene of RhoA and MRTF-A signaling that contributes to protection from ischemia/reperfusion injury in the mouse heart. Chapters 3 and 4 examine the role of two transcriptional pathways that are activated through GPCRs and RhoA, one utilizing the transcriptional co-activator MRTF-A and SRF, the other the transcriptional co-activator YAP and TEAD. Chapter 3 focuses on their unique pathways of activation and convergent effects on gene regulation. Chapter 4 identifies genes regulated uniquely or commonly via YAP and MRTF-A, defines their differential roles and that of their downstream target genes in regulating cell invasion, migration, adhesion, and proliferation, as well as, effects of their genetic deletion on growth and lethality of glioblastoma tumors in the in vivo mouse brain. Finally, Chapter 5 summarizes and identifies remaining questions and extension of studies presented in previous chapters." @default.
- W2918384611 created "2019-03-11" @default.
- W2918384611 creator A5001716015 @default.
- W2918384611 date "2016-01-01" @default.
- W2918384611 modified "2023-09-26" @default.
- W2918384611 title "GPCR and RhoA-Mediated Transcriptional Regulation" @default.
- W2918384611 hasPublicationYear "2016" @default.
- W2918384611 type Work @default.
- W2918384611 sameAs 2918384611 @default.
- W2918384611 citedByCount "0" @default.
- W2918384611 crossrefType "journal-article" @default.
- W2918384611 hasAuthorship W2918384611A5001716015 @default.
- W2918384611 hasConcept C104317684 @default.
- W2918384611 hasConcept C135285700 @default.
- W2918384611 hasConcept C165864922 @default.
- W2918384611 hasConcept C27153228 @default.
- W2918384611 hasConcept C2777093181 @default.
- W2918384611 hasConcept C54355233 @default.
- W2918384611 hasConcept C62478195 @default.
- W2918384611 hasConcept C86339819 @default.
- W2918384611 hasConcept C86803240 @default.
- W2918384611 hasConcept C88045685 @default.
- W2918384611 hasConcept C95444343 @default.
- W2918384611 hasConceptScore W2918384611C104317684 @default.
- W2918384611 hasConceptScore W2918384611C135285700 @default.
- W2918384611 hasConceptScore W2918384611C165864922 @default.
- W2918384611 hasConceptScore W2918384611C27153228 @default.
- W2918384611 hasConceptScore W2918384611C2777093181 @default.
- W2918384611 hasConceptScore W2918384611C54355233 @default.
- W2918384611 hasConceptScore W2918384611C62478195 @default.
- W2918384611 hasConceptScore W2918384611C86339819 @default.
- W2918384611 hasConceptScore W2918384611C86803240 @default.
- W2918384611 hasConceptScore W2918384611C88045685 @default.
- W2918384611 hasConceptScore W2918384611C95444343 @default.
- W2918384611 hasLocation W29183846111 @default.
- W2918384611 hasOpenAccess W2918384611 @default.
- W2918384611 hasPrimaryLocation W29183846111 @default.
- W2918384611 hasRelatedWork W1523902960 @default.
- W2918384611 hasRelatedWork W1984506063 @default.
- W2918384611 hasRelatedWork W2006959050 @default.
- W2918384611 hasRelatedWork W2008742248 @default.
- W2918384611 hasRelatedWork W2029516652 @default.
- W2918384611 hasRelatedWork W2032427485 @default.
- W2918384611 hasRelatedWork W2053837284 @default.
- W2918384611 hasRelatedWork W2095209881 @default.
- W2918384611 hasRelatedWork W2133189575 @default.
- W2918384611 hasRelatedWork W2588297910 @default.
- W2918384611 hasRelatedWork W2766096988 @default.
- W2918384611 hasRelatedWork W2770083058 @default.
- W2918384611 hasRelatedWork W2883830230 @default.
- W2918384611 hasRelatedWork W2914044487 @default.
- W2918384611 hasRelatedWork W2947645009 @default.
- W2918384611 hasRelatedWork W3001275729 @default.
- W2918384611 hasRelatedWork W3172100945 @default.
- W2918384611 hasRelatedWork W3173715208 @default.
- W2918384611 hasRelatedWork W645800910 @default.
- W2918384611 hasRelatedWork W804635950 @default.
- W2918384611 isParatext "false" @default.
- W2918384611 isRetracted "false" @default.
- W2918384611 magId "2918384611" @default.
- W2918384611 workType "article" @default.