Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918419355> ?p ?o ?g. }
- W2918419355 endingPage "794" @default.
- W2918419355 startingPage "784" @default.
- W2918419355 abstract "Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the gastric mucosa of 60–95% of pigs at slaughter age, and is associated with chronic gastritis, decreased weight gain, and ulcers. Here, we show that experimental H. suis infection changes the mucin composition and glycosylation, decreasing the amount of H. suis-binding glycan structures in the pig gastric mucus niche. Similarly, the H. suis-binding ability of mucins from H. pylori-infected humans is lower than that of noninfected individuals. Furthermore, the H. suis growth-inhibiting effect of mucins from both noninfected humans and pigs is replaced by a growth-enhancing effect by mucins from infected individuals/pigs. Thus, Helicobacter spp. infections impair the mucus barrier by decreasing the H. suis-binding ability of the mucins and by decreasing the antiprolific activity that mucins can have on H. suis. Inhibition of these mucus-based defenses creates a more stable and inhabitable niche for H. suis. This is likely of importance for long-term colonization and outcome of infection, and reversing these impairments may have therapeutic benefits." @default.
- W2918419355 created "2019-03-11" @default.
- W2918419355 creator A5007390513 @default.
- W2918419355 creator A5007470010 @default.
- W2918419355 creator A5020306466 @default.
- W2918419355 creator A5033836686 @default.
- W2918419355 creator A5044653645 @default.
- W2918419355 creator A5052738405 @default.
- W2918419355 creator A5057607733 @default.
- W2918419355 creator A5072630098 @default.
- W2918419355 creator A5075227577 @default.
- W2918419355 creator A5085508347 @default.
- W2918419355 creator A5087164752 @default.
- W2918419355 creator A5087816012 @default.
- W2918419355 date "2019-05-01" @default.
- W2918419355 modified "2023-10-03" @default.
- W2918419355 title "Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins" @default.
- W2918419355 cites W1766399424 @default.
- W2918419355 cites W1893127417 @default.
- W2918419355 cites W1970532044 @default.
- W2918419355 cites W1973067432 @default.
- W2918419355 cites W1986311439 @default.
- W2918419355 cites W1992322620 @default.
- W2918419355 cites W2009645460 @default.
- W2918419355 cites W2017020122 @default.
- W2918419355 cites W2024375133 @default.
- W2918419355 cites W2025688642 @default.
- W2918419355 cites W2026407856 @default.
- W2918419355 cites W2030434248 @default.
- W2918419355 cites W2032563466 @default.
- W2918419355 cites W2039478605 @default.
- W2918419355 cites W2042457965 @default.
- W2918419355 cites W2044255471 @default.
- W2918419355 cites W2047043794 @default.
- W2918419355 cites W2049880802 @default.
- W2918419355 cites W2054416052 @default.
- W2918419355 cites W2062503200 @default.
- W2918419355 cites W2067296088 @default.
- W2918419355 cites W2073498732 @default.
- W2918419355 cites W2074904156 @default.
- W2918419355 cites W2078436176 @default.
- W2918419355 cites W2080796863 @default.
- W2918419355 cites W2084512022 @default.
- W2918419355 cites W2102637432 @default.
- W2918419355 cites W2103057333 @default.
- W2918419355 cites W2104156944 @default.
- W2918419355 cites W2109678144 @default.
- W2918419355 cites W2114798556 @default.
- W2918419355 cites W2124994169 @default.
- W2918419355 cites W2136293523 @default.
- W2918419355 cites W2164102364 @default.
- W2918419355 cites W2165392027 @default.
- W2918419355 cites W2168139379 @default.
- W2918419355 cites W2230253643 @default.
- W2918419355 cites W2417504246 @default.
- W2918419355 cites W2489696178 @default.
- W2918419355 cites W2572146215 @default.
- W2918419355 cites W2595041680 @default.
- W2918419355 cites W2617833612 @default.
- W2918419355 cites W2618278488 @default.
- W2918419355 cites W2625821816 @default.
- W2918419355 cites W2770541458 @default.
- W2918419355 cites W2797468131 @default.
- W2918419355 cites W2807944186 @default.
- W2918419355 cites W2904568842 @default.
- W2918419355 doi "https://doi.org/10.1038/s41385-019-0154-4" @default.
- W2918419355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30846831" @default.
- W2918419355 hasPublicationYear "2019" @default.
- W2918419355 type Work @default.
- W2918419355 sameAs 2918419355 @default.
- W2918419355 citedByCount "21" @default.
- W2918419355 countsByYear W29184193552019 @default.
- W2918419355 countsByYear W29184193552020 @default.
- W2918419355 countsByYear W29184193552021 @default.
- W2918419355 countsByYear W29184193552022 @default.
- W2918419355 countsByYear W29184193552023 @default.
- W2918419355 crossrefType "journal-article" @default.
- W2918419355 hasAuthorship W2918419355A5007390513 @default.
- W2918419355 hasAuthorship W2918419355A5007470010 @default.
- W2918419355 hasAuthorship W2918419355A5020306466 @default.
- W2918419355 hasAuthorship W2918419355A5033836686 @default.
- W2918419355 hasAuthorship W2918419355A5044653645 @default.
- W2918419355 hasAuthorship W2918419355A5052738405 @default.
- W2918419355 hasAuthorship W2918419355A5057607733 @default.
- W2918419355 hasAuthorship W2918419355A5072630098 @default.
- W2918419355 hasAuthorship W2918419355A5075227577 @default.
- W2918419355 hasAuthorship W2918419355A5085508347 @default.
- W2918419355 hasAuthorship W2918419355A5087164752 @default.
- W2918419355 hasAuthorship W2918419355A5087816012 @default.
- W2918419355 hasBestOaLocation W29184193551 @default.
- W2918419355 hasConcept C108625454 @default.
- W2918419355 hasConcept C153911025 @default.
- W2918419355 hasConcept C179264091 @default.
- W2918419355 hasConcept C18903297 @default.
- W2918419355 hasConcept C203014093 @default.
- W2918419355 hasConcept C206212055 @default.
- W2918419355 hasConcept C2776409635 @default.
- W2918419355 hasConcept C2776460866 @default.