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• W2918440345 endingPage "e13270" @default.
• W2918440345 startingPage "e13270" @default.
• W2918440345 abstract "Several million patients with liver cirrhosis suffer minimal hepatic encephalopathy (MHE), with mild cognitive and coordination impairments that reduce their quality of life and life span. Hyperammonaemia and peripheral inflammation act synergistically to induce these neurological alterations. We propose that MHE appearance is because of the changes in peripheral immune system, which are transmitted to brain, leading to neuroinflammation that alters neurotransmission leading to cognitive and motor alterations. We summarize studies showing that MHE in cirrhotic patients is associated with alterations in the immune system and that patients died with HE show neuroinflammation in cerebellum, with microglial and astrocytic activation and Purkinje cell loss. We also summarize studies in animal models of MHE on the role of peripheral inflammation in neuroinflammation induction, how neuroinflammation alters neurotransmission and how this leads to cognitive and motor alterations. These studies identify therapeutic targets and treatments that improve cognitive and motor function. Rats with MHE show neuroinflammation in hippocampus and altered NMDA and AMPA receptor membrane expression, which impairs spatial learning and memory. Neuroinflammation in cerebellum is associated with altered GABA transporters and extracellular GABA, which impair motor coordination and learning in a Y maze. These alterations are reversed by treatments that reduce peripheral inflammation (anti-TNFα, ibuprofen), neuroinflammation (sulphoraphane, p38 inhibitors), GABAergic tone (bicuculline, pregnenolone sulphate) or increase extracellular cGMP (sildenafil or cGMP). The mechanisms identified would also occur in other chronic diseases associated with inflammation, aging and some mental and neurodegenerative diseases. Treatments that improve MHE may also be beneficial to treat these pathologies." @default.
• W2918440345 created "2019-03-11" @default.
• W2918440345 creator A5040703004 @default.
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• W2918440345 date "2019-03-22" @default.
• W2918440345 modified "2023-10-12" @default.
• W2918440345 title "Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications" @default.
• W2918440345 cites W1525492054 @default.
• W2918440345 cites W1568573049 @default.
• W2918440345 cites W1837726506 @default.
• W2918440345 cites W1884361550 @default.
• W2918440345 cites W1914468664 @default.
• W2918440345 cites W1952040396 @default.
• W2918440345 cites W1965008709 @default.
• W2918440345 cites W1966161025 @default.
• W2918440345 cites W1966279100 @default.
• W2918440345 cites W1970314590 @default.
• W2918440345 cites W1970718497 @default.
• W2918440345 cites W1973661816 @default.
• W2918440345 cites W1977406411 @default.
• W2918440345 cites W1978744572 @default.
• W2918440345 cites W1980366917 @default.
• W2918440345 cites W1982049192 @default.
• W2918440345 cites W1984527360 @default.
• W2918440345 cites W1988995007 @default.
• W2918440345 cites W1992587025 @default.
• W2918440345 cites W1992793984 @default.
• W2918440345 cites W1997322387 @default.
• W2918440345 cites W2000843849 @default.
• W2918440345 cites W2010141336 @default.
• W2918440345 cites W2014782195 @default.
• W2918440345 cites W2015669226 @default.
• W2918440345 cites W2025660075 @default.
• W2918440345 cites W2026352845 @default.
• W2918440345 cites W2027230535 @default.
• W2918440345 cites W2028495451 @default.
• W2918440345 cites W2030207241 @default.
• W2918440345 cites W2034099577 @default.
• W2918440345 cites W2037015340 @default.
• W2918440345 cites W2044931055 @default.
• W2918440345 cites W2046391118 @default.
• W2918440345 cites W2048332099 @default.
• W2918440345 cites W2052741633 @default.
• W2918440345 cites W2053575220 @default.
• W2918440345 cites W2066175640 @default.
• W2918440345 cites W2067740038 @default.
• W2918440345 cites W2071108101 @default.
• W2918440345 cites W2071640821 @default.
• W2918440345 cites W2079385693 @default.
• W2918440345 cites W2084731734 @default.
• W2918440345 cites W2088910001 @default.
• W2918440345 cites W2092247085 @default.
• W2918440345 cites W2092749570 @default.
• W2918440345 cites W2097605564 @default.
• W2918440345 cites W2108772424 @default.
• W2918440345 cites W2111312680 @default.
• W2918440345 cites W2113243367 @default.
• W2918440345 cites W2121719064 @default.
• W2918440345 cites W2124627119 @default.
• W2918440345 cites W2128945841 @default.
• W2918440345 cites W2134209166 @default.
• W2918440345 cites W2141823993 @default.
• W2918440345 cites W2143162826 @default.
• W2918440345 cites W2181851876 @default.
• W2918440345 cites W2284220587 @default.
• W2918440345 cites W2341354305 @default.
• W2918440345 cites W2343031459 @default.
• W2918440345 cites W2390593254 @default.
• W2918440345 cites W2415549038 @default.
• W2918440345 cites W2518729378 @default.
• W2918440345 cites W2519357203 @default.
• W2918440345 cites W2527444812 @default.
• W2918440345 cites W2548359101 @default.
• W2918440345 cites W2584651005 @default.
• W2918440345 cites W2591872130 @default.
• W2918440345 cites W2736484177 @default.
• W2918440345 cites W2752477272 @default.
• W2918440345 cites W2780202192 @default.
• W2918440345 cites W2792049503 @default.
• W2918440345 cites W2796509698 @default.
• W2918440345 cites W2803323241 @default.
• W2918440345 cites W2806887888 @default.
• W2918440345 cites W2808591612 @default.
• W2918440345 cites W2883246269 @default.
• W2918440345 cites W2885688677 @default.
• W2918440345 cites W2902225300 @default.
• W2918440345 cites W2903675394 @default.
• W2918440345 cites W2909671450 @default.

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