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- W2918443099 abstract "Introduction: Cortisol effects on the brain are exerted through two distinct receptors, inducing complex and even opposite effects on the cerebral structures implicated in the various cognitive functions. High cortisol may also have deleterious effects on the brain structures and contribute to neurodegeneration, in particular Alzheimer’s disease (AD), via different mechanisms. Objective: To examine the interrelationships between cortisol, cognitive impairment and AD. Methods: Review of the literature. Results: Clinical studies found that elevated cortisol was associated with poorer overall cognitive functioning, as well as with poorer episodic memory, executive functioning, language, spatial memory, processing speed, and social cognition; while in animals, glucocorticoid administration resulted in cognitive impairment and abnormal behavior. In cognitively healthy subjects, higher cortisol levels have been associated with an increased risk of cognitive decline and AD. Subjects with dementia and Mild Cognitive Impairment (MCI) due to AD have been found to have higher CSF cortisol levels than cognitively healthy controls. Elevated CSF cortisol may also be associated with a more rapid cognitive decline in MCI due to AD. Elevated cortisol levels have been also found in delirium. High cortisol may mediate the impact of stressful life events, high neuroticism, depression, sleep disturbances, as well as cardiovascular risk factors on cognitive performance, neurodegeneration, and cognitive decline. High cortisol may also exert neurotoxic effects on the hippocampus, and promote oxidative stress and amyloid β peptide toxicity. Further possible underlying mechanisms include the interactions of cortisol with inflammatory mediators, neurotransmitters, and growth factors. Conclusions: Elevated cortisol levels may exert detrimental effects on cognition and contribute to AD pathology. Further studies are needed to investigate cortisol-reducing and glucocorticoidreceptor modulating interventions to prevent cognitive decline." @default.
- W2918443099 created "2019-03-11" @default.
- W2918443099 creator A5010454922 @default.
- W2918443099 creator A5022295403 @default.
- W2918443099 date "2019-03-01" @default.
- W2918443099 modified "2023-10-13" @default.
- W2918443099 title "High Cortisol and the Risk of Dementia and Alzheimer’s Disease: A Review of the Literature" @default.
- W2918443099 cites W1548760166 @default.
- W2918443099 cites W1562629562 @default.
- W2918443099 cites W1840594301 @default.
- W2918443099 cites W1872109420 @default.
- W2918443099 cites W1905023764 @default.
- W2918443099 cites W1965755188 @default.
- W2918443099 cites W1965943690 @default.
- W2918443099 cites W1966762774 @default.
- W2918443099 cites W1977368796 @default.
- W2918443099 cites W1979068472 @default.
- W2918443099 cites W1980228489 @default.
- W2918443099 cites W1987339739 @default.
- W2918443099 cites W1987375729 @default.
- W2918443099 cites W1991347149 @default.
- W2918443099 cites W1992356087 @default.
- W2918443099 cites W1994944795 @default.
- W2918443099 cites W2002401669 @default.
- W2918443099 cites W2003982930 @default.
- W2918443099 cites W2004196011 @default.
- W2918443099 cites W2005355670 @default.
- W2918443099 cites W2007018171 @default.
- W2918443099 cites W2008301967 @default.
- W2918443099 cites W2012780111 @default.
- W2918443099 cites W2017543460 @default.
- W2918443099 cites W2018503115 @default.
- W2918443099 cites W2020195361 @default.
- W2918443099 cites W2020751568 @default.
- W2918443099 cites W2023210721 @default.
- W2918443099 cites W2023648659 @default.
- W2918443099 cites W2025184266 @default.
- W2918443099 cites W2025468569 @default.
- W2918443099 cites W2026867638 @default.
- W2918443099 cites W2028676090 @default.
- W2918443099 cites W2029404396 @default.
- W2918443099 cites W2029438618 @default.
- W2918443099 cites W2031353556 @default.
- W2918443099 cites W2032461473 @default.
- W2918443099 cites W2034019648 @default.
- W2918443099 cites W2034340220 @default.
- W2918443099 cites W2036672386 @default.
- W2918443099 cites W2038031942 @default.
- W2918443099 cites W2043205976 @default.
- W2918443099 cites W2043522411 @default.
- W2918443099 cites W2046181148 @default.
- W2918443099 cites W2051288982 @default.
- W2918443099 cites W2053910117 @default.
- W2918443099 cites W2056678962 @default.
- W2918443099 cites W2057034512 @default.
- W2918443099 cites W2057772151 @default.
- W2918443099 cites W2061233374 @default.
- W2918443099 cites W2064886500 @default.
- W2918443099 cites W2066947947 @default.
- W2918443099 cites W2067664488 @default.
- W2918443099 cites W2076385524 @default.
- W2918443099 cites W2078772317 @default.
- W2918443099 cites W2079409065 @default.
- W2918443099 cites W2085425790 @default.
- W2918443099 cites W2089189148 @default.
- W2918443099 cites W2089297337 @default.
- W2918443099 cites W2090002169 @default.
- W2918443099 cites W2091164849 @default.
- W2918443099 cites W2091365059 @default.
- W2918443099 cites W2094616122 @default.
- W2918443099 cites W2100551304 @default.
- W2918443099 cites W2100827473 @default.
- W2918443099 cites W2101253814 @default.
- W2918443099 cites W2105917287 @default.
- W2918443099 cites W2113180182 @default.
- W2918443099 cites W2126226668 @default.
- W2918443099 cites W2134697757 @default.
- W2918443099 cites W2136742966 @default.
- W2918443099 cites W2136754329 @default.
- W2918443099 cites W2138723087 @default.
- W2918443099 cites W2139190597 @default.
- W2918443099 cites W2139434784 @default.
- W2918443099 cites W2142789104 @default.
- W2918443099 cites W2142827889 @default.
- W2918443099 cites W2143925867 @default.
- W2918443099 cites W2144101679 @default.
- W2918443099 cites W2150037324 @default.
- W2918443099 cites W2151466405 @default.
- W2918443099 cites W2151595908 @default.
- W2918443099 cites W2153352515 @default.
- W2918443099 cites W2154712992 @default.
- W2918443099 cites W2155083520 @default.
- W2918443099 cites W2156893181 @default.
- W2918443099 cites W2161290803 @default.
- W2918443099 cites W2163857054 @default.
- W2918443099 cites W2166027549 @default.
- W2918443099 cites W2166949480 @default.
- W2918443099 cites W2167402997 @default.
- W2918443099 cites W2168387026 @default.
- W2918443099 cites W2169771574 @default.