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- W2918443405 abstract "Experiment and modeling were combined to understand inhibition of the alanine-serine-cysteine-1 (asc1) transporter. The structure–activity relationship (SAR) was explored with synthesis of analogues of BMS-466442. Direct target interaction and binding site location between TM helices 6 and 10 were confirmed via site directed mutagenesis. Computational modeling suggested the inhibitor binds via competitive occupation of the orthosteric site while also blocking the movement of TM helices that are required for transport." @default.
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- W2918443405 date "2019-03-01" @default.
- W2918443405 modified "2023-09-26" @default.
- W2918443405 title "Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442" @default.
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- W2918443405 doi "https://doi.org/10.1021/acschemneuro.9b00019" @default.
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