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• W2918452357 abstract "Insulin dysregulation encompasses abnormalities in insulin metabolism, including hyperinsulinaemia and insulin resistance. These abnormalities cause diseases in horses and humans, including laminitis and type-2 diabetes mellitus, respectively. This project investigated the role of incretins, and their receptors, in equine insulin dysregulation, and also examined the inhibitory effect of sweet-taste receptor antagonists on intestinal glucose uptake. The project discovered that incretin action and glucose uptake can be attenuated in horses using incretin, and sweet-taste receptor, antagonists, respectively. This is a novel approach to reducing hyperinsulinaemia. Thus, these pathways should be further investigated as novel therapies for metabolic syndrome and laminitis." @default.
• W2918452357 created "2019-03-11" @default.
• W2918452357 creator A5042084169 @default.
• W2918452357 date "2018-11-19" @default.
• W2918452357 modified "2023-10-01" @default.
• W2918452357 title "The Role of the Equine Enteroinsular Axis in Insulin Dysregulation: In Vitro Mechanistic Insights for Disease Prevention" @default.
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