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- W2918496356 abstract "Introduction: Precision Medicine is a concept dependent on a deeper understanding of the individual and his illness. The understanding of schizophrenic disease stands on categorical classifications which exclude the disease’s ethiological and pathogenic features. Telomeric dysfunction, a way of measuring accelerated ageing, has been associated with some diseases. The purpose of this paper is to understand the relationship between telomere size and schizophrenia, and to infer if it can be used in Precision Medicine. Materials and methods: We searched for scientific articles using Medline database, via Pubmed and ISI Web . We used the he following terms: schizophrenia, precision medicine, psychiatry, pathogeny, ethiology, telomere, cross-sectional studies. After an exclusion process, 51 articles were analysed. Results: Most of the analysed articles are cross-sectional. The evidence is inconsistent. There are articles that claim that telomere length decreases, others do not find statistically significant differences and others advocate an increase in telomere length in schizophrenia. Several arguments are listed for these results. Discussion: The conflicting results seem to be mainly explained by the limitations of cross-sectional studies. Further longitudinal studies are proposed. Furthermore, such results can also be explained by the multifactorial nature of schizophrenia. Conclusion: Because Precision Medicine needs advanced and detailed data, and the study of telomeres in schizophrenia isn’t reproducible, its usefulness in this disease remains uncertain." @default.
- W2918496356 created "2019-03-11" @default.
- W2918496356 creator A5082610815 @default.
- W2918496356 date "2019-06-11" @default.
- W2918496356 modified "2023-09-23" @default.
- W2918496356 title "Precision Medicine and Schizophrenia: What about Telomere Length?" @default.
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