FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918637819> ?p ?o ?g. }

• W2918637819 abstract "Group A Streptococcus (GAS) is a major human pathogen, which is associated with a wide spectrum of invasive diseases, such as pharyngitis, scarlet fever, rheumatic fever, and streptococcal toxic shock syndrome (STSS). It is hypothesized that differences in GAS pathogenicity are related to the acquisition of diverse bacteriophages (phages). Nevertheless, the GAS genome also harbors clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (cas) genes, which play an important role in eliminating foreign DNA, including those of phages. However, the structure of prophages in GAS strains is mosaic, and the phylogenetic relationship between prophages and CRISPR is not clear. In this study, we analyzed CRISPR and prophage structure using 118 complete genome sequences of GAS strains to elucidate the relationship between two genomic elements. Additionally, phylogenetic and M-type analyses were performed. Of the 118 GAS strains, 80 harbored type I-C and/or II-A CRISPR/cas loci. A total of 553 spacer sequences were identified from CRISPR/cas loci and sorted into 229 patterns. We identified and classified 373 prophages into 14 groups. Some prophage groups shared a common integration site, and were related to M-type. We further investigated the correlation between spacer sequences and prophages. Of the 229 spacer sequence patterns, 203 were similar to that of other GAS prophages. No spacer showed similarity with that of a specific prophage group with mutL integration site. Moreover, the average number of prophages in strains with type II-A CRISPR was significantly less than that in type I-C CRISPR and non-CRISPR strains. However, there was no statistical difference between the average number of prophages in type I-C strains and that in non-CRISPR strains. Our results indicated that type II-A CRISPR may play an important role in eliminating phages and that the prophage integration site may be an important criterion for the acceptance of foreign DNA by GAS. M type, spacer sequence, and prophage group data were correlated with the phylogenetic relationships of GAS. Therefore, we hypothesize that genetic characteristics and/or phylogenetic relationships of GAS may be estimated by analyzing its spacer sequences." @default.
• W2918637819 created "2019-03-11" @default.
• W2918637819 creator A5008158617 @default.
• W2918637819 creator A5026975906 @default.
• W2918637819 creator A5035351957 @default.
• W2918637819 creator A5041558862 @default.
• W2918637819 creator A5064494933 @default.
• W2918637819 creator A5076504113 @default.
• W2918637819 creator A5086402871 @default.
• W2918637819 date "2019-01-28" @default.
• W2918637819 modified "2023-10-15" @default.
• W2918637819 title "Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus" @default.
• W2918637819 cites W1966840911 @default.
• W2918637819 cites W1980220877 @default.
• W2918637819 cites W1986171241 @default.
• W2918637819 cites W1998405590 @default.
• W2918637819 cites W2015105695 @default.
• W2918637819 cites W2017721099 @default.
• W2918637819 cites W2027591298 @default.
• W2918637819 cites W2034201571 @default.
• W2918637819 cites W2038838144 @default.
• W2918637819 cites W2055043387 @default.
• W2918637819 cites W2060573994 @default.
• W2918637819 cites W2069678357 @default.
• W2918637819 cites W2077911023 @default.
• W2918637819 cites W2086208676 @default.
• W2918637819 cites W2090176539 @default.
• W2918637819 cites W2096093282 @default.
• W2918637819 cites W2099249298 @default.
• W2918637819 cites W2099836442 @default.
• W2918637819 cites W2099860226 @default.
• W2918637819 cites W2100970948 @default.
• W2918637819 cites W2117059491 @default.
• W2918637819 cites W2119043925 @default.
• W2918637819 cites W2122673596 @default.
• W2918637819 cites W2127391962 @default.
• W2918637819 cites W2127774996 @default.
• W2918637819 cites W2127834937 @default.
• W2918637819 cites W2130124027 @default.
• W2918637819 cites W2131527797 @default.
• W2918637819 cites W2132026894 @default.
• W2918637819 cites W2134941170 @default.
• W2918637819 cites W2141516076 @default.
• W2918637819 cites W2144123881 @default.
• W2918637819 cites W2147805408 @default.
• W2918637819 cites W2155090350 @default.
• W2918637819 cites W2161834179 @default.
• W2918637819 cites W2166192874 @default.
• W2918637819 cites W2166689012 @default.
• W2918637819 cites W2168696662 @default.
• W2918637819 cites W2168933209 @default.
• W2918637819 cites W2170255645 @default.
• W2918637819 cites W2171359378 @default.
• W2918637819 cites W2199695484 @default.
• W2918637819 cites W2588193147 @default.
• W2918637819 cites W2783502622 @default.
• W2918637819 doi "https://doi.org/10.1186/s12866-019-1393-y" @default.
• W2918637819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6348661" @default.
• W2918637819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30691408" @default.
• W2918637819 hasPublicationYear "2019" @default.
• W2918637819 type Work @default.
• W2918637819 sameAs 2918637819 @default.
• W2918637819 citedByCount "11" @default.
• W2918637819 countsByYear W29186378192020 @default.
• W2918637819 countsByYear W29186378192021 @default.
• W2918637819 countsByYear W29186378192022 @default.
• W2918637819 crossrefType "journal-article" @default.
• W2918637819 hasAuthorship W2918637819A5008158617 @default.
• W2918637819 hasAuthorship W2918637819A5026975906 @default.
• W2918637819 hasAuthorship W2918637819A5035351957 @default.
• W2918637819 hasAuthorship W2918637819A5041558862 @default.
• W2918637819 hasAuthorship W2918637819A5064494933 @default.
• W2918637819 hasAuthorship W2918637819A5076504113 @default.
• W2918637819 hasAuthorship W2918637819A5086402871 @default.
• W2918637819 hasBestOaLocation W29186378191 @default.
• W2918637819 hasConcept C104317684 @default.
• W2918637819 hasConcept C141231307 @default.
• W2918637819 hasConcept C193252679 @default.
• W2918637819 hasConcept C2776441376 @default.
• W2918637819 hasConcept C2779306812 @default.
• W2918637819 hasConcept C2779489039 @default.
• W2918637819 hasConcept C523546767 @default.
• W2918637819 hasConcept C54355233 @default.
• W2918637819 hasConcept C547475151 @default.
• W2918637819 hasConcept C73445445 @default.
• W2918637819 hasConcept C86803240 @default.
• W2918637819 hasConcept C98108389 @default.
• W2918637819 hasConceptScore W2918637819C104317684 @default.
• W2918637819 hasConceptScore W2918637819C141231307 @default.
• W2918637819 hasConceptScore W2918637819C193252679 @default.
• W2918637819 hasConceptScore W2918637819C2776441376 @default.
• W2918637819 hasConceptScore W2918637819C2779306812 @default.
• W2918637819 hasConceptScore W2918637819C2779489039 @default.
• W2918637819 hasConceptScore W2918637819C523546767 @default.
• W2918637819 hasConceptScore W2918637819C54355233 @default.
• W2918637819 hasConceptScore W2918637819C547475151 @default.
• W2918637819 hasConceptScore W2918637819C73445445 @default.
• W2918637819 hasConceptScore W2918637819C86803240 @default.
• W2918637819 hasConceptScore W2918637819C98108389 @default.
• W2918637819 hasFunder F4320311405 @default.

• next