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• W2918708768 abstract "RAR β plays a critical role in cancer progression and is associated with several types of human cancer. It remains unclear, however, whether it is linked to the clinicopathological parameters of colorectal cancer (CRC). We therefore determined the expression of RAR β protein in patients with primary CRC and examined its relationship with clinical outcomes. RAR β expression in 234 samples of CRC patients and matched benign noncancerous tumors was detected by immunohistochemistry. RAR β mRNA expression was confirmed using the TCGA and Oncomine databases. COX regression analysis and Kaplan–Meier survival analysis were performed to determine the relationship between RAR β expression and CRC prognosis. Our results show that high expression of RAR β correlated with better prognosis in CRC patients. RAR β expression in CRC specimens was clearly lower than in peritumoral specimens (30.8% vs 58.8%, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>) and significantly correlated with gender (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:msup><mml:mrow><mml:mi>χ</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>3.926</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.048</mml:mn></mml:math>), tumor differentiation (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:msup><mml:mrow><mml:mi>χ</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>5.978</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.014</mml:mn></mml:math>), and tumor stage (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:msup><mml:mrow><mml:mi>χ</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>6.642</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.036</mml:mn></mml:math>). Multivariate analyses further revealed that low RAR β expression (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.001</mml:mn></mml:math>), distant metastasis (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.001</mml:mn></mml:math>), tissue differentiation (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.006</mml:mn></mml:math>), and tumor stage (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.002</mml:mn></mml:math>) were associated with overall survival in CRC patients. In addition, Kaplan–Meier analysis indicated that increased RAR β expression in cytoplasm (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.001</mml:mn></mml:math>) and early tumor TNM stage (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.030</mml:mn></mml:math>) was associated with a more favorable outcome in patients with CRC. In conclusion, RAR β expression was strongly correlated with several clinicopathological factors of CRC and may represent a favorable prognostic marker in patients with CRC." @default.
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• W2918708768 date "2019-03-03" @default.
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• W2918708768 title "High Expression of RARβ Is a Favorable Factor in Colorectal Cancer" @default.
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• W2918708768 doi "https://doi.org/10.1155/2019/7138754" @default.
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