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- W2918713061 abstract "Pancreatic cancer tops fourth in cancer-related deaths in US adults because of its poor diagnosis and the lack of early markers thus resulted in increased metastasis cases. Treatment options for such cases are limited and exhibit minimum response to treatment. Research for the past five decades demonstrated that epithelial-to-mesenchymal transition (EMT) is the major contributing factor for the cancer progression, invasion, and metastasis. Numerous xenograft animal- and cell line-based studies state that transcription factors (Snail, Slug, Twist, and ZEB1) that regulate EMT are involved in cancer progression. Recent insights show that various cell signaling pathways (TGF-β, Wnt/β-catenin, Notch, and TNF-α) that regulate EMT also contribute to invasion and metastasis in pancreatic ductal adenocarcinoma patients. The 50 years of study provide the fascinating inputs highlighting the role of EMT in pancreatic cancer progression, unraveling its role in chemoresistance. In particular, the impact of EMT in experimental therapies remains debatable, while the drug discovery strategies of combinational therapies by inhibition of EMT along with chemotherapy deserve consideration in pancreatic cancer. In this chapter, we encapsulate the critical research findings on EMT-associated chemoresistance and its mechanisms in pancreatic cancers." @default.
- W2918713061 created "2019-03-11" @default.
- W2918713061 creator A5035798595 @default.
- W2918713061 creator A5060647223 @default.
- W2918713061 creator A5078243996 @default.
- W2918713061 date "2019-01-01" @default.
- W2918713061 modified "2023-10-14" @default.
- W2918713061 title "EMT Contributes to Chemoresistance in Pancreatic Cancer" @default.
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