Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918722435> ?p ?o ?g. }
- W2918722435 abstract "Sustained neurotransmission requires the tight coupling of synaptic vesicle (SV) exocytosis and endocytosis. The mechanisms underlying this coupling are poorly understood. We tested the hypothesis that a cGMP-dependent protein kinase (PKG), encoded by the foraging (for) gene in Drosophila melanogaster, is critical for this process using a for null mutant, genomic rescues, and tissue specific rescues. We uncoupled FOR's exocytic and endocytic functions in neurotransmission using a temperature-sensitive shibire mutant in conjunction with fluorescein-assisted light inactivation of FOR. We discovered a dual role for presynaptic FOR, where FOR inhibits SV exocytosis during low frequency stimulation by negatively regulating presynaptic Ca2+ levels and maintains neurotransmission during high frequency stimulation by facilitating SV endocytosis. Additionally, glial FOR negatively regulated nerve terminal growth through TGF-β signaling and this developmental effect was independent from FOR's effects on neurotransmission. Overall, FOR plays a critical role in coupling SV exocytosis and endocytosis, thereby balancing these two components to maintain sustained neurotransmission." @default.
- W2918722435 created "2019-03-11" @default.
- W2918722435 creator A5028532429 @default.
- W2918722435 creator A5054041436 @default.
- W2918722435 creator A5065255123 @default.
- W2918722435 creator A5078671314 @default.
- W2918722435 date "2019-01-01" @default.
- W2918722435 modified "2023-10-14" @default.
- W2918722435 title "Distinct functions of a cGMP-dependent protein kinase in nerve terminal growth and synaptic vesicle cycling" @default.
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