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• W2918775529 abstract "Chronic drug doping has a great influence on the functional and morphological properties of brain tissues. However, the underlying mechanism related to these variations remains unclear. Since there are evidences showing that iron concentration affects the synthesis of dopamine and monoamine metabolism, in the present work, we propose to use quantitative susceptibility mapping (QSM) to investigate the iron distribution in the brain tissues. To achieve this, 9 heroin users (HUs) and 2 controls (CLs) were recruited for MRI scanning. QSM images were obtained firstly with STI-suite and then registered and segmented with a QSM atlas and parcellation maps. The results demonstrated that, the HUs experienced higher iron accumulation in putamen, globus pallidus, caudate nucleus and thalamus than CLs. Our findings showed that there is a link between the morphological changes and the iron concentration variations in the brain of Hus. This would be helpful for understanding the underlying mechanism by which drug addiction affects the brain and providing the guidance for effective treatment strategies." @default.
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• W2918775529 date "2018-08-01" @default.
• W2918775529 modified "2023-10-08" @default.
• W2918775529 title "Quantitative Susceptibility Mapping for Drug-Addicted Human Brain" @default.
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• W2918775529 doi "https://doi.org/10.1109/icsp.2018.8652449" @default.
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