FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918818254> ?p ?o ?g. }

• W2918818254 abstract "Abstract Hepatocyte-like cells (HLCs) derived from induced pluripotent stem cells (iPSCs) provide a renewable source of cells for drug discovery, disease modelling and cell-based therapies. Here, by using GRO-Seq we provide the first genome-wide analysis of the nascent RNAs in iPSCs, HLCs and primary hepatocytes to extend our understanding of the transcriptional changes occurring during hepatic differentiation process. We demonstrate that a large fraction of hepatocyte-specific genes are regulated at transcriptional level and identify hundreds of differentially expressed non-coding RNAs (ncRNAs), including primary miRNAs (pri-miRNAs) and long non-coding RNAs (lncRNAs). Differentiation induced alternative transcription start site (TSS) usage between the cell types as evidenced for miR-221/222 and miR-3613/15a/16-1 clusters. We demonstrate that lncRNAs and coding genes are tightly co-expressed and could thus be co-regulated. Finally, we identified sets of transcriptional regulators that might drive transcriptional changes during hepatocyte differentiation. These included RARG, E2F1, SP1 and FOXH1, which were associated with the down-regulated transcripts, and hepatocyte-specific TFs such as FOXA1, FOXA2, HNF1B, HNF4A and CEBPA, as well as RXR, PPAR, AP-1, JUNB, JUND and BATF, which were associated with up-regulated transcripts. In summary, this study clarifies the role of regulatory ncRNAs and TFs in differentiation of HLCs from iPSCs." @default.
• W2918818254 created "2019-03-11" @default.
• W2918818254 creator A5002221149 @default.
• W2918818254 creator A5011313978 @default.
• W2918818254 creator A5015092410 @default.
• W2918818254 creator A5027482380 @default.
• W2918818254 creator A5031281862 @default.
• W2918818254 creator A5057631116 @default.
• W2918818254 creator A5061025378 @default.
• W2918818254 creator A5063194021 @default.
• W2918818254 creator A5072289816 @default.
• W2918818254 creator A5089225816 @default.
• W2918818254 date "2019-03-05" @default.
• W2918818254 modified "2023-10-02" @default.
• W2918818254 title "Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation" @default.
• W2918818254 cites W1527719302 @default.
• W2918818254 cites W1585431367 @default.
• W2918818254 cites W1658877244 @default.
• W2918818254 cites W1936011157 @default.
• W2918818254 cites W1971578941 @default.
• W2918818254 cites W1981482520 @default.
• W2918818254 cites W1983601196 @default.
• W2918818254 cites W1987315409 @default.
• W2918818254 cites W1995754186 @default.
• W2918818254 cites W1997643107 @default.
• W2918818254 cites W1998871958 @default.
• W2918818254 cites W1999746344 @default.
• W2918818254 cites W2002880141 @default.
• W2918818254 cites W2004966039 @default.
• W2918818254 cites W2007844697 @default.
• W2918818254 cites W2008695914 @default.
• W2918818254 cites W2014677321 @default.
• W2918818254 cites W2020755558 @default.
• W2918818254 cites W2029919331 @default.
• W2918818254 cites W2037363723 @default.
• W2918818254 cites W2041956619 @default.
• W2918818254 cites W2044830131 @default.
• W2918818254 cites W2047356483 @default.
• W2918818254 cites W2059023271 @default.
• W2918818254 cites W2063815548 @default.
• W2918818254 cites W2075498275 @default.
• W2918818254 cites W2091198887 @default.
• W2918818254 cites W2091514601 @default.
• W2918818254 cites W2095659684 @default.
• W2918818254 cites W2104519300 @default.
• W2918818254 cites W2104925243 @default.
• W2918818254 cites W2110335719 @default.
• W2918818254 cites W2112541034 @default.
• W2918818254 cites W2116521322 @default.
• W2918818254 cites W2116881442 @default.
• W2918818254 cites W2117350148 @default.
• W2918818254 cites W2119197345 @default.
• W2918818254 cites W2119726708 @default.
• W2918818254 cites W2120633445 @default.
• W2918818254 cites W2121510721 @default.
• W2918818254 cites W2123680132 @default.
• W2918818254 cites W2123806948 @default.
• W2918818254 cites W2124985265 @default.
• W2918818254 cites W2127059331 @default.
• W2918818254 cites W2132556256 @default.
• W2918818254 cites W2136162491 @default.
• W2918818254 cites W2141314779 @default.
• W2918818254 cites W2150098952 @default.
• W2918818254 cites W2155268095 @default.
• W2918818254 cites W2160288586 @default.
• W2918818254 cites W2167656033 @default.
• W2918818254 cites W2168290712 @default.
• W2918818254 cites W2168602111 @default.
• W2918818254 cites W2198153867 @default.
• W2918818254 cites W2228951539 @default.
• W2918818254 cites W2321561488 @default.
• W2918818254 cites W2334245120 @default.
• W2918818254 cites W2340149197 @default.
• W2918818254 cites W2341117915 @default.
• W2918818254 cites W2415183924 @default.
• W2918818254 cites W2520228482 @default.
• W2918818254 cites W2521169638 @default.
• W2918818254 cites W2606434976 @default.
• W2918818254 cites W2611717748 @default.
• W2918818254 cites W2621774891 @default.
• W2918818254 cites W2625523848 @default.
• W2918818254 cites W2734905682 @default.
• W2918818254 cites W2737677209 @default.
• W2918818254 cites W2739736711 @default.
• W2918818254 cites W2741045901 @default.
• W2918818254 cites W2768491523 @default.
• W2918818254 cites W2786204582 @default.
• W2918818254 cites W2796278270 @default.
• W2918818254 cites W2804205552 @default.
• W2918818254 cites W2910329543 @default.
• W2918818254 cites W4231914016 @default.
• W2918818254 doi "https://doi.org/10.1038/s41598-019-39215-0" @default.
• W2918818254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6401154" @default.
• W2918818254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30837492" @default.
• W2918818254 hasPublicationYear "2019" @default.
• W2918818254 type Work @default.
• W2918818254 sameAs 2918818254 @default.
• W2918818254 citedByCount "19" @default.
• W2918818254 countsByYear W29188182542018 @default.
• W2918818254 countsByYear W29188182542019 @default.

• next