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- W2918829954 abstract "MgO nanoparticles (MgONPs) have been widely used as antibacterial agents with the advantages of them being nontoxic and their unique biological properties. In this study, we synthesized MgONPs by co-precipitation method and characterized them by XRD, SEM and EDS analysis. The antibiofilm activity of MgONPs as observed quantitatively by crystal violet assay and their action on biofilm architecture were assessed in both Gram-positive and Gram negative uropathogenic bacteria. In addition, the cytotoxic effect of synthesized MgONPs was evaluated against human breast cancer, MCF-7 cells. The morphological changes of apoptosis were observed by Acridine Orange/Ethidium Bromide (AO/EB) staining using a fluorescent microscope. MgONPs inhibited more than 50% of the biofilms in most of the tested uropathogenic bacteria; notably 80% inhibition in the case of K. pneumoniae. MgONPs successfully inhibited the viability of MCF-7 cells at a concentration of 50 μg.mL−l. Given their antibiofilm properties; MgONPs could be used as a potential nanomaterial for in vivo applications such as coating for a medical implant." @default.
- W2918829954 created "2019-03-11" @default.
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- W2918829954 date "2019-03-01" @default.
- W2918829954 modified "2023-10-13" @default.
- W2918829954 title "An investigation of antibiofilm and cytotoxic property of MgO nanoparticles" @default.
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- W2918829954 doi "https://doi.org/10.1016/j.bcab.2019.101069" @default.
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