Matches in SemOpenAlex for { <https://semopenalex.org/work/W2918891954> ?p ?o ?g. }
- W2918891954 endingPage "388" @default.
- W2918891954 startingPage "379" @default.
- W2918891954 abstract "Context: Fumonisins (FNs), a group of mycotoxins produced mainly by Fusarium species, are ubiquitous food contaminants, especially for maize. Fumonisin B1 (FB1) caused severe toxicities in farm animals, induced kidney and liver tumours in rodents and is associated with many human adverse health effects, including oesophageal cancer. International Agency for Research on Cancer (IARC) categorizes FB1 as a possible human carcinogen (Group 2B). Inhibition of ceramide synthesis and disruption of sphingolipids metabolism are well studied as the major mechanisms of FB1-induced toxicity. Increases in sphinganine (Sa) and decrease in sphingosine (So) levels and their ratio are validated biomarkers of FB1 effects.Methods: In this study, we measured urinary levels of Sa, So and Sa/So in 284 children aged 1–14 years who consume maize as a staple diet. Exfoliated cells from urine were processed and sphingolipids quantified by High Pressure Liquid Chromatography.Results and conclusions: Sa and So were detectable in 95.07% and 98.94% of samples, respectively. Creatinine adjusted mean levels and standard deviation of Sa, So and Sa/So ratio were 1.23 ± 2.18, 4.99 ± 8.3 and 0.296 ± 0.587 nM. These results further confirmed the findings in studies with human adults, i.e. urinary Sa, So levels and Sa/So ratio are good biomarkers to assess FNs exposure in children." @default.
- W2918891954 created "2019-03-11" @default.
- W2918891954 creator A5002435767 @default.
- W2918891954 creator A5014800722 @default.
- W2918891954 creator A5030482226 @default.
- W2918891954 creator A5045754980 @default.
- W2918891954 creator A5075544463 @default.
- W2918891954 creator A5078709209 @default.
- W2918891954 date "2019-03-20" @default.
- W2918891954 modified "2023-10-01" @default.
- W2918891954 title "Validation of urinary sphingolipid metabolites as biomarker of effect for fumonisins exposure in Kenyan children" @default.
- W2918891954 cites W1222445959 @default.
- W2918891954 cites W1535433473 @default.
- W2918891954 cites W1580732042 @default.
- W2918891954 cites W1595478999 @default.
- W2918891954 cites W1601116039 @default.
- W2918891954 cites W1808685515 @default.
- W2918891954 cites W1969659458 @default.
- W2918891954 cites W1971813644 @default.
- W2918891954 cites W1972190191 @default.
- W2918891954 cites W1974782561 @default.
- W2918891954 cites W1985062075 @default.
- W2918891954 cites W1998166232 @default.
- W2918891954 cites W1999465667 @default.
- W2918891954 cites W2001043662 @default.
- W2918891954 cites W2004169620 @default.
- W2918891954 cites W2009688135 @default.
- W2918891954 cites W2012835825 @default.
- W2918891954 cites W2016210649 @default.
- W2918891954 cites W2020367910 @default.
- W2918891954 cites W2026596958 @default.
- W2918891954 cites W2027527321 @default.
- W2918891954 cites W2028789155 @default.
- W2918891954 cites W2032400188 @default.
- W2918891954 cites W2042384439 @default.
- W2918891954 cites W2047084393 @default.
- W2918891954 cites W2051499502 @default.
- W2918891954 cites W2056946374 @default.
- W2918891954 cites W2057191831 @default.
- W2918891954 cites W2057417054 @default.
- W2918891954 cites W2061439496 @default.
- W2918891954 cites W2065523141 @default.
- W2918891954 cites W2066269932 @default.
- W2918891954 cites W2069028107 @default.
- W2918891954 cites W2079884576 @default.
- W2918891954 cites W2082924787 @default.
- W2918891954 cites W2083552161 @default.
- W2918891954 cites W2085664921 @default.
- W2918891954 cites W2088604446 @default.
- W2918891954 cites W2090636982 @default.
- W2918891954 cites W2098197031 @default.
- W2918891954 cites W2111645679 @default.
- W2918891954 cites W2112241819 @default.
- W2918891954 cites W2112269495 @default.
- W2918891954 cites W2114448478 @default.
- W2918891954 cites W2119594829 @default.
- W2918891954 cites W2144379159 @default.
- W2918891954 cites W2146043903 @default.
- W2918891954 cites W2148849694 @default.
- W2918891954 cites W2154400377 @default.
- W2918891954 cites W2164956492 @default.
- W2918891954 cites W2183470075 @default.
- W2918891954 cites W2327135260 @default.
- W2918891954 cites W2625800782 @default.
- W2918891954 cites W2790589748 @default.
- W2918891954 doi "https://doi.org/10.1080/1354750x.2019.1587510" @default.
- W2918891954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30821509" @default.
- W2918891954 hasPublicationYear "2019" @default.
- W2918891954 type Work @default.
- W2918891954 sameAs 2918891954 @default.
- W2918891954 citedByCount "16" @default.
- W2918891954 countsByYear W29188919542019 @default.
- W2918891954 countsByYear W29188919542020 @default.
- W2918891954 countsByYear W29188919542021 @default.
- W2918891954 countsByYear W29188919542022 @default.
- W2918891954 countsByYear W29188919542023 @default.
- W2918891954 crossrefType "journal-article" @default.
- W2918891954 hasAuthorship W2918891954A5002435767 @default.
- W2918891954 hasAuthorship W2918891954A5014800722 @default.
- W2918891954 hasAuthorship W2918891954A5030482226 @default.
- W2918891954 hasAuthorship W2918891954A5045754980 @default.
- W2918891954 hasAuthorship W2918891954A5075544463 @default.
- W2918891954 hasAuthorship W2918891954A5078709209 @default.
- W2918891954 hasConcept C114246631 @default.
- W2918891954 hasConcept C121608353 @default.
- W2918891954 hasConcept C126322002 @default.
- W2918891954 hasConcept C151730666 @default.
- W2918891954 hasConcept C170493617 @default.
- W2918891954 hasConcept C185592680 @default.
- W2918891954 hasConcept C190283241 @default.
- W2918891954 hasConcept C197934379 @default.
- W2918891954 hasConcept C2777851122 @default.
- W2918891954 hasConcept C2778431908 @default.
- W2918891954 hasConcept C2778703144 @default.
- W2918891954 hasConcept C2779343474 @default.
- W2918891954 hasConcept C2780026642 @default.
- W2918891954 hasConcept C2780306776 @default.
- W2918891954 hasConcept C2781197716 @default.