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- W2918985478 abstract "Zearalenone (ZEA), a non-steroidal estrogen mycotoxin produced by several species of Fusarium fungi, can be metabolized into many other derivatives by microorganisms, plants, animals and humans. It can affect mammalian reproductive capability by impacting the synthesis and secretion of sex hormones, including testosterone, estradiol and progesterone. This review summarizes the mechanisms in which ZEA and its derivatives disturb the synthesis and secretion of sex steroid hormones. Because of its structural analogy to estrogen, ZEA and its derivatives can exert a variety of estrogen-like effects and engage in estrogen negative feedback regulation, which can result in mediating the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the pituitary gland. ZEA and its derivatives can ultimately reduce the number of Leydig cells and granulosa cells by inducing oxidative stress, endoplasmic reticulum (ER) stress, cell cycle arrest, cell apoptosis, and cell regeneration delay. Additionally, they can disrupt the mitochondrial structure and influence mitochondrial functions through overproduction of reactive oxygen species (ROS) and aberrant autophagy signaling ways. Finally, ZEA and its derivatives can disturb the expressions and activities of the related steroidogenic enzymes through cross talking between membrane and nuclear estrogen receptors." @default.
- W2918985478 created "2019-03-11" @default.
- W2918985478 creator A5009730421 @default.
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- W2918985478 creator A5091333279 @default.
- W2918985478 date "2019-04-01" @default.
- W2918985478 modified "2023-10-16" @default.
- W2918985478 title "Effects of zearalenone and its derivatives on the synthesis and secretion of mammalian sex steroid hormones: A review" @default.
- W2918985478 cites W1118248241 @default.
- W2918985478 cites W1503671947 @default.
- W2918985478 cites W1549886276 @default.
- W2918985478 cites W1591186166 @default.
- W2918985478 cites W1846980064 @default.
- W2918985478 cites W1967925956 @default.
- W2918985478 cites W1969754826 @default.
- W2918985478 cites W1970282707 @default.
- W2918985478 cites W1972266551 @default.
- W2918985478 cites W1975277279 @default.
- W2918985478 cites W1977033369 @default.
- W2918985478 cites W1978761842 @default.
- W2918985478 cites W1981234399 @default.
- W2918985478 cites W1982020456 @default.
- W2918985478 cites W1982049574 @default.
- W2918985478 cites W1988902793 @default.
- W2918985478 cites W1990059944 @default.
- W2918985478 cites W1991590342 @default.
- W2918985478 cites W1992049516 @default.
- W2918985478 cites W1995276261 @default.
- W2918985478 cites W1997238548 @default.
- W2918985478 cites W1997792093 @default.
- W2918985478 cites W1999620455 @default.
- W2918985478 cites W2002436258 @default.
- W2918985478 cites W2003590725 @default.
- W2918985478 cites W2005145242 @default.
- W2918985478 cites W2007464399 @default.
- W2918985478 cites W2014762324 @default.
- W2918985478 cites W2019466915 @default.
- W2918985478 cites W2020479941 @default.
- W2918985478 cites W2021491682 @default.
- W2918985478 cites W2022051063 @default.
- W2918985478 cites W2023110320 @default.
- W2918985478 cites W2023374241 @default.
- W2918985478 cites W2026303105 @default.
- W2918985478 cites W2026388727 @default.
- W2918985478 cites W2027328852 @default.
- W2918985478 cites W2031277435 @default.
- W2918985478 cites W2035134750 @default.
- W2918985478 cites W2036670300 @default.
- W2918985478 cites W2037508331 @default.
- W2918985478 cites W2037864697 @default.
- W2918985478 cites W2038501506 @default.
- W2918985478 cites W2038977640 @default.
- W2918985478 cites W2042523946 @default.
- W2918985478 cites W2044328030 @default.
- W2918985478 cites W2049135889 @default.
- W2918985478 cites W2049566660 @default.
- W2918985478 cites W2049588822 @default.
- W2918985478 cites W2051802492 @default.
- W2918985478 cites W2055659588 @default.
- W2918985478 cites W2057223282 @default.
- W2918985478 cites W2062162313 @default.
- W2918985478 cites W2062656956 @default.
- W2918985478 cites W2066962102 @default.
- W2918985478 cites W2070065930 @default.
- W2918985478 cites W2073575443 @default.
- W2918985478 cites W2073978111 @default.
- W2918985478 cites W2074969091 @default.
- W2918985478 cites W2084913036 @default.
- W2918985478 cites W2085975200 @default.
- W2918985478 cites W2086568113 @default.
- W2918985478 cites W2087683721 @default.
- W2918985478 cites W2092699248 @default.
- W2918985478 cites W2098214350 @default.
- W2918985478 cites W2101897405 @default.
- W2918985478 cites W2107910981 @default.
- W2918985478 cites W2117278034 @default.
- W2918985478 cites W2117803941 @default.
- W2918985478 cites W2118487113 @default.
- W2918985478 cites W2118786143 @default.
- W2918985478 cites W2121594363 @default.
- W2918985478 cites W2127541329 @default.
- W2918985478 cites W2128461781 @default.
- W2918985478 cites W2131007152 @default.
- W2918985478 cites W2137637548 @default.
- W2918985478 cites W2140819525 @default.
- W2918985478 cites W2147203421 @default.
- W2918985478 cites W2147322409 @default.