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- W2919011602 endingPage "410" @default.
- W2919011602 startingPage "398" @default.
- W2919011602 abstract "The identification of T-bet as a key transcription factor associated with the development of IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and in resistance to many intracellular infections. This idea was reinforced by initial reports showing that T-bet-deficient mice were more susceptible to pathogens that survived within the lysosomal system of macrophages. However, subsequent studies revealed IFNγ-dependent, T-bet-independent pathways of resistance to diverse classes of microorganisms that occupy other intracellular niches. Consequently, a more complex picture has emerged of how T-bet and the related transcription factor eomesodermin (EOMES) coordinate many facets of the immune response to bona fide pathogens as well as commensals. This article provides an overview of the discovery and evolutionary relationship between T-bet and EOMES and highlights the studies that have uncovered broader functions of T-bet in innate and adaptive immunity and in the development of the effector and memory T cell populations that mediate long-term resistance to infection." @default.
- W2919011602 created "2019-03-11" @default.
- W2919011602 creator A5014118991 @default.
- W2919011602 creator A5064693777 @default.
- W2919011602 creator A5066347052 @default.
- W2919011602 date "2019-03-07" @default.
- W2919011602 modified "2023-10-12" @default.
- W2919011602 title "The evolving role of T-bet in resistance to infection" @default.
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