Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919106615> ?p ?o ?g. }
- W2919106615 abstract "Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly post-transcriptionally, chromatin accessibility plays a fundamental role in transcription initiation control. We have previously shown that High Mobility Group B protein from Trypanosoma cruzi (TcHMGB) can bind DNA in vitro. Here, we show that TcHMGB also acts as an architectural protein in vivo, since the overexpression of this protein induces changes in the nuclear structure, mainly the reduction of the nucleolus and a decrease in the heterochromatin:euchromatin ratio. Epimastigote replication rate was markedly reduced presumably due to a delayed cell cycle progression with accumulation of parasites in G2/M phase and impaired cytokinesis. Some functions involved in pathogenesis were also altered in TcHMGB-overexpressing parasites, like the decreased efficiency of trypomastigotes to infect cells in vitro, the reduction of intracellular amastigotes replication and the number of released trypomastigotes. Taken together, our results suggest that the TcHMGB protein is a pleiotropic player that controls cell phenotype and it is involved in key cellular processes." @default.
- W2919106615 created "2019-03-11" @default.
- W2919106615 creator A5003333190 @default.
- W2919106615 creator A5033731058 @default.
- W2919106615 creator A5040634752 @default.
- W2919106615 creator A5050248420 @default.
- W2919106615 creator A5070823338 @default.
- W2919106615 creator A5074090300 @default.
- W2919106615 creator A5076372249 @default.
- W2919106615 creator A5090335628 @default.
- W2919106615 date "2019-01-17" @default.
- W2919106615 modified "2023-10-10" @default.
- W2919106615 title "Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity" @default.
- W2919106615 cites W1525509305 @default.
- W2919106615 cites W168035116 @default.
- W2919106615 cites W1934638475 @default.
- W2919106615 cites W1954656319 @default.
- W2919106615 cites W1966521400 @default.
- W2919106615 cites W1970022594 @default.
- W2919106615 cites W1971718824 @default.
- W2919106615 cites W1991556097 @default.
- W2919106615 cites W1992082488 @default.
- W2919106615 cites W2001391951 @default.
- W2919106615 cites W2016513686 @default.
- W2919106615 cites W2018743269 @default.
- W2919106615 cites W2019461837 @default.
- W2919106615 cites W2021217831 @default.
- W2919106615 cites W2021863432 @default.
- W2919106615 cites W2031712001 @default.
- W2919106615 cites W2044111397 @default.
- W2919106615 cites W2045594331 @default.
- W2919106615 cites W2059529139 @default.
- W2919106615 cites W2061905133 @default.
- W2919106615 cites W2064389061 @default.
- W2919106615 cites W2066371247 @default.
- W2919106615 cites W2076259638 @default.
- W2919106615 cites W2077399716 @default.
- W2919106615 cites W2079686164 @default.
- W2919106615 cites W2080413629 @default.
- W2919106615 cites W2094128593 @default.
- W2919106615 cites W2099889296 @default.
- W2919106615 cites W2102034886 @default.
- W2919106615 cites W2106648515 @default.
- W2919106615 cites W2108709147 @default.
- W2919106615 cites W2111806909 @default.
- W2919106615 cites W2118915580 @default.
- W2919106615 cites W2121293790 @default.
- W2919106615 cites W2123588419 @default.
- W2919106615 cites W2139251571 @default.
- W2919106615 cites W2140787483 @default.
- W2919106615 cites W2147523009 @default.
- W2919106615 cites W2148173743 @default.
- W2919106615 cites W2150820635 @default.
- W2919106615 cites W2155159495 @default.
- W2919106615 cites W2157284742 @default.
- W2919106615 cites W2158385764 @default.
- W2919106615 cites W2164086894 @default.
- W2919106615 cites W2166130130 @default.
- W2919106615 cites W2311115959 @default.
- W2919106615 cites W2338889021 @default.
- W2919106615 cites W2342794464 @default.
- W2919106615 cites W2439473447 @default.
- W2919106615 cites W2470058227 @default.
- W2919106615 cites W2532855413 @default.
- W2919106615 cites W2556533107 @default.
- W2919106615 cites W2586189198 @default.
- W2919106615 cites W2586448862 @default.
- W2919106615 cites W2587292039 @default.
- W2919106615 cites W2592102995 @default.
- W2919106615 cites W2618421521 @default.
- W2919106615 cites W2771049087 @default.
- W2919106615 cites W2790890772 @default.
- W2919106615 cites W2796814589 @default.
- W2919106615 cites W2800448430 @default.
- W2919106615 cites W2807677855 @default.
- W2919106615 doi "https://doi.org/10.1038/s41598-018-36718-0" @default.
- W2919106615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6336821" @default.
- W2919106615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30655631" @default.
- W2919106615 hasPublicationYear "2019" @default.
- W2919106615 type Work @default.
- W2919106615 sameAs 2919106615 @default.
- W2919106615 citedByCount "12" @default.
- W2919106615 countsByYear W29191066152019 @default.
- W2919106615 countsByYear W29191066152020 @default.
- W2919106615 countsByYear W29191066152021 @default.
- W2919106615 countsByYear W29191066152022 @default.
- W2919106615 crossrefType "journal-article" @default.
- W2919106615 hasAuthorship W2919106615A5003333190 @default.
- W2919106615 hasAuthorship W2919106615A5033731058 @default.
- W2919106615 hasAuthorship W2919106615A5040634752 @default.
- W2919106615 hasAuthorship W2919106615A5050248420 @default.
- W2919106615 hasAuthorship W2919106615A5070823338 @default.
- W2919106615 hasAuthorship W2919106615A5074090300 @default.
- W2919106615 hasAuthorship W2919106615A5076372249 @default.
- W2919106615 hasAuthorship W2919106615A5090335628 @default.
- W2919106615 hasBestOaLocation W29191066151 @default.
- W2919106615 hasConcept C100924687 @default.
- W2919106615 hasConcept C103435993 @default.
- W2919106615 hasConcept C104317684 @default.
- W2919106615 hasConcept C136764020 @default.