FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919179612> ?p ?o ?g. }

• W2919179612 endingPage "30" @default.
• W2919179612 startingPage "24" @default.
• W2919179612 abstract "There remains a substantial residual risk of ischaemic heart disease (IHD) despite optimal low-density lipoprotein cholesterol (LDLC) reduction. Part of this risk may be attributable to remnant cholesterol, which is carried in triglyceride-rich lipoproteins. We evaluated the relationship between remnant cholesterol and coronary atherosclerotic plaque burden assessed non-invasively by computed tomography coronary angiography (CTCA) in patients with suspected coronary artery disease (CAD).This was a multicentre study of 587 patients who had a CTCA and fasting lipid profile within 3 months. Calculated remnant cholesterol was total cholesterol minus LDLC minus high-density lipoprotein cholesterol (HDLC). Significant coronary atherosclerotic burden was defined as CT-Leaman score >5 (CT-LeSc), an established predictor of cardiac events. Mean age was 61 ± 12 years and mean pretest probability of CAD was 23.2 ± 19.8%. LDLC levels were <1.8 mmol/L in 134 patients (23%), of whom 82% were statin-treated. Patients with CT-LeSc >5 had higher mean remnant cholesterol than those with CT-LeSc ≤5 (0.76 ± 0.36 mmol/L vs. 0.58 ± 0.33 mmol/L, p = 0.01). On univariable analysis, remnant cholesterol (p = 0.01), LDLC (p = 0.002) and HDLC (p < 0.001) levels predicted CT-LeSc >5, whilst triglycerides (p = 0.79) had no association with CT-LeSc >5. On multivariable analysis in the subset of patients with optimal LDLC levels, remnant cholesterol levels remained predictive of CT-LeSc >5 (OR 3.87, 95% confidence interval 1.34-7.55, p = 0.004), adjusted for HDLC and traditional risk factors.Remnant cholesterol levels are associated with significant coronary atherosclerotic burden as assessed by CTCA, even in patients with optimal LDLC levels. Future studies examining whether lowering of remnant cholesterol can reduce residual IHD risk are warranted." @default.
• W2919179612 created "2019-03-11" @default.
• W2919179612 creator A5011102609 @default.
• W2919179612 creator A5027703152 @default.
• W2919179612 creator A5037376535 @default.
• W2919179612 creator A5043099782 @default.
• W2919179612 creator A5049076239 @default.
• W2919179612 creator A5054767679 @default.
• W2919179612 creator A5055849986 @default.
• W2919179612 creator A5057735331 @default.
• W2919179612 creator A5063047637 @default.
• W2919179612 creator A5071411367 @default.
• W2919179612 creator A5082142800 @default.
• W2919179612 creator A5086342077 @default.
• W2919179612 date "2019-05-01" @default.
• W2919179612 modified "2023-10-03" @default.
• W2919179612 title "Remnant cholesterol and coronary atherosclerotic plaque burden assessed by computed tomography coronary angiography" @default.
• W2919179612 cites W1453335796 @default.
• W2919179612 cites W2026624820 @default.
• W2919179612 cites W2040770080 @default.
• W2919179612 cites W2040937148 @default.
• W2919179612 cites W2068030410 @default.
• W2919179612 cites W2070402811 @default.
• W2919179612 cites W2071936488 @default.
• W2919179612 cites W2073106629 @default.
• W2919179612 cites W2090087329 @default.
• W2919179612 cites W2100800328 @default.
• W2919179612 cites W2101616997 @default.
• W2919179612 cites W2108018713 @default.
• W2919179612 cites W2108169164 @default.
• W2919179612 cites W2109095803 @default.
• W2919179612 cites W2113760558 @default.
• W2919179612 cites W2118825330 @default.
• W2919179612 cites W2121568629 @default.
• W2919179612 cites W2124481954 @default.
• W2919179612 cites W2132196134 @default.
• W2919179612 cites W2148092884 @default.
• W2919179612 cites W2150100875 @default.
• W2919179612 cites W2159449551 @default.
• W2919179612 cites W2163381397 @default.
• W2919179612 cites W2164089346 @default.
• W2919179612 cites W2165605025 @default.
• W2919179612 cites W2170210469 @default.
• W2919179612 cites W2275234007 @default.
• W2919179612 cites W2286999219 @default.
• W2919179612 cites W2342925409 @default.
• W2919179612 cites W2473077508 @default.
• W2919179612 cites W2501649131 @default.
• W2919179612 cites W2509381650 @default.
• W2919179612 cites W2509676484 @default.
• W2919179612 cites W2548121913 @default.
• W2919179612 cites W2567249252 @default.
• W2919179612 cites W2597657713 @default.
• W2919179612 cites W4236673002 @default.
• W2919179612 doi "https://doi.org/10.1016/j.atherosclerosis.2019.02.019" @default.
• W2919179612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30870704" @default.
• W2919179612 hasPublicationYear "2019" @default.
• W2919179612 type Work @default.
• W2919179612 sameAs 2919179612 @default.
• W2919179612 citedByCount "35" @default.
• W2919179612 countsByYear W29191796122019 @default.
• W2919179612 countsByYear W29191796122020 @default.
• W2919179612 countsByYear W29191796122021 @default.
• W2919179612 countsByYear W29191796122022 @default.
• W2919179612 countsByYear W29191796122023 @default.
• W2919179612 crossrefType "journal-article" @default.
• W2919179612 hasAuthorship W2919179612A5011102609 @default.
• W2919179612 hasAuthorship W2919179612A5027703152 @default.
• W2919179612 hasAuthorship W2919179612A5037376535 @default.
• W2919179612 hasAuthorship W2919179612A5043099782 @default.
• W2919179612 hasAuthorship W2919179612A5049076239 @default.
• W2919179612 hasAuthorship W2919179612A5054767679 @default.
• W2919179612 hasAuthorship W2919179612A5055849986 @default.
• W2919179612 hasAuthorship W2919179612A5057735331 @default.
• W2919179612 hasAuthorship W2919179612A5063047637 @default.
• W2919179612 hasAuthorship W2919179612A5071411367 @default.
• W2919179612 hasAuthorship W2919179612A5082142800 @default.
• W2919179612 hasAuthorship W2919179612A5086342077 @default.
• W2919179612 hasConcept C126322002 @default.
• W2919179612 hasConcept C164705383 @default.
• W2919179612 hasConcept C2778163477 @default.
• W2919179612 hasConcept C2778213512 @default.
• W2919179612 hasConcept C2991716557 @default.
• W2919179612 hasConcept C3019004856 @default.
• W2919179612 hasConcept C44249647 @default.
• W2919179612 hasConcept C500558357 @default.
• W2919179612 hasConcept C71924100 @default.
• W2919179612 hasConceptScore W2919179612C126322002 @default.
• W2919179612 hasConceptScore W2919179612C164705383 @default.
• W2919179612 hasConceptScore W2919179612C2778163477 @default.
• W2919179612 hasConceptScore W2919179612C2778213512 @default.
• W2919179612 hasConceptScore W2919179612C2991716557 @default.
• W2919179612 hasConceptScore W2919179612C3019004856 @default.
• W2919179612 hasConceptScore W2919179612C44249647 @default.
• W2919179612 hasConceptScore W2919179612C500558357 @default.
• W2919179612 hasConceptScore W2919179612C71924100 @default.
• W2919179612 hasFunder F4320334705 @default.
• W2919179612 hasLocation W29191796121 @default.

• next