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- W2919212025 abstract "Extracellular matrix (ECM) maintains the structural integrity of tissues and regulates cell and tissue functions. ECM is comprised of fibrillar proteins, proteoglycans (PGs), glycosaminoglycans, and glycoproteins, creating a heterogeneous but well-orchestrated network. This network communicates with resident cells via cell-surface receptors. In particular, integrins, CD44, discoidin domain receptors, and cell-surface PGs and additionally voltage-gated ion channels can interact with ECM components, regulating signaling cascades as well as cytoskeleton configuration. The interplay of ECM with recipient cells is enriched by the extracellular vesicles, as they accommodate ECM, signaling, and cytoskeleton molecules in their cargo. Along with the numerous biological properties that ECM can modify, autophagy and angiogenesis, which are critical for tissue homeostasis, are included. Throughout development and disease onset and progression, ECM endures rearrangement to fulfill cellular requirements. The main responsible molecules for tissue remodeling are ECM-degrading enzymes including matrix metalloproteinases, plasminogen activators, cathepsins, and hyaluronidases, which can modify the ECM structure and function in a dynamic mode. A brief summary of the complex interplay between ECM macromolecules and cells in tissues and the contribution of ECM in tissue homeostasis and diseases is given." @default.
- W2919212025 created "2019-03-11" @default.
- W2919212025 creator A5002627973 @default.
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- W2919212025 date "2019-01-01" @default.
- W2919212025 modified "2023-09-30" @default.
- W2919212025 title "The Complex Interplay Between Extracellular Matrix and Cells in Tissues" @default.
- W2919212025 cites W1226975619 @default.
- W2919212025 cites W1558905924 @default.
- W2919212025 cites W1576773659 @default.
- W2919212025 cites W1642834507 @default.
- W2919212025 cites W1756122328 @default.
- W2919212025 cites W1794039655 @default.
- W2919212025 cites W1853780315 @default.
- W2919212025 cites W1858075833 @default.
- W2919212025 cites W1861497351 @default.
- W2919212025 cites W1893337122 @default.
- W2919212025 cites W1903604055 @default.
- W2919212025 cites W1943317391 @default.
- W2919212025 cites W1965498876 @default.
- W2919212025 cites W1965611576 @default.
- W2919212025 cites W1976237200 @default.
- W2919212025 cites W1982533712 @default.
- W2919212025 cites W1985842761 @default.
- W2919212025 cites W1986909751 @default.
- W2919212025 cites W1987329859 @default.
- W2919212025 cites W1987473368 @default.
- W2919212025 cites W1996462110 @default.
- W2919212025 cites W1997450131 @default.
- W2919212025 cites W1999023235 @default.
- W2919212025 cites W2003380614 @default.
- W2919212025 cites W2009948849 @default.
- W2919212025 cites W2011136203 @default.
- W2919212025 cites W2011862459 @default.
- W2919212025 cites W2013271982 @default.
- W2919212025 cites W2015912825 @default.
- W2919212025 cites W2032586069 @default.
- W2919212025 cites W2032700869 @default.
- W2919212025 cites W2035640198 @default.
- W2919212025 cites W2035734134 @default.
- W2919212025 cites W2037632318 @default.
- W2919212025 cites W2038005900 @default.
- W2919212025 cites W2038431330 @default.
- W2919212025 cites W2042966680 @default.
- W2919212025 cites W2044625443 @default.
- W2919212025 cites W2045295282 @default.
- W2919212025 cites W2045502903 @default.
- W2919212025 cites W2045973674 @default.
- W2919212025 cites W2051025909 @default.
- W2919212025 cites W2052467200 @default.
- W2919212025 cites W2053617956 @default.
- W2919212025 cites W2056852515 @default.
- W2919212025 cites W2058229406 @default.
- W2919212025 cites W2061546218 @default.
- W2919212025 cites W2063392635 @default.
- W2919212025 cites W2064039937 @default.
- W2919212025 cites W2068694666 @default.
- W2919212025 cites W2071123870 @default.
- W2919212025 cites W2072320843 @default.
- W2919212025 cites W2086101092 @default.
- W2919212025 cites W2088128469 @default.
- W2919212025 cites W2089753996 @default.
- W2919212025 cites W2090985686 @default.
- W2919212025 cites W2097847761 @default.
- W2919212025 cites W2098259366 @default.
- W2919212025 cites W2099422381 @default.
- W2919212025 cites W2099750732 @default.
- W2919212025 cites W2103048323 @default.
- W2919212025 cites W2114016572 @default.
- W2919212025 cites W2115124692 @default.
- W2919212025 cites W2117692326 @default.
- W2919212025 cites W2118417553 @default.
- W2919212025 cites W2118834593 @default.
- W2919212025 cites W2120020050 @default.
- W2919212025 cites W2123158441 @default.
- W2919212025 cites W2124323004 @default.
- W2919212025 cites W2125360811 @default.
- W2919212025 cites W2127466034 @default.
- W2919212025 cites W2128881726 @default.
- W2919212025 cites W2130255071 @default.
- W2919212025 cites W2131441161 @default.
- W2919212025 cites W2137103099 @default.
- W2919212025 cites W2139519365 @default.
- W2919212025 cites W2145039249 @default.
- W2919212025 cites W2145449209 @default.
- W2919212025 cites W2151324822 @default.
- W2919212025 cites W2153315863 @default.
- W2919212025 cites W2162977739 @default.
- W2919212025 cites W2167938256 @default.
- W2919212025 cites W2169595400 @default.
- W2919212025 cites W2170852633 @default.