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• W2919212908 abstract "The ESX-1 (ESAT-6 system 1) secretion system plays a conserved role in the virulence of diverse mycobacterial pathogens, including the human pathogen Mycobacterium tuberculosis and M. marinum, an environmental mycobacterial species. The ESX-1 system promotes the secretion of protein virulence factors to the extracytoplasmic environment. The secretion of these proteins triggers the host response by lysing the phagosome during macrophage infection. Using proteomic analyses of the M. marinum secretome in the presence and absence of a functional ESX-1 system, we and others have hypothesized that MMAR_2894, a PE family protein, is a potential ESX-1 substrate in M. marinum We used genetic and quantitative proteomic approaches to determine if MMAR_2894 is secreted by the ESX-1 system, and we defined the requirement of MMAR_2894 for ESX-1-mediated secretion and virulence. We show that MMAR_2894 is secreted by the ESX-1 system in M. marinum and is itself required for the optimal secretion of the known ESX-1 substrates in M. marinum Moreover, we found that MMAR_2894 was differentially required for hemolysis and cytolysis of macrophages, two lytic activities ascribed to the M. marinum ESX-1 system.IMPORTANCE Both Mycobacterium tuberculosis, the cause of human tuberculosis (TB), and Mycobacterium marinum, a pathogen of ectotherms, use the ESX-1 secretion system to cause disease. There are many established similarities between the ESX-1 systems in M. tuberculosis and in M. marinum Yet the two bacteria infect different hosts, hinting at species-specific functions of the ESX-1 system. Our findings demonstrate that MMAR_2894 is a PE protein secreted by the ESX-1 system of M. marinum We show that MMAR_2894 is required for the optimal secretion of mycobacterial proteins required for disease. Because the MMAR_2894 gene is not conserved in M. tuberculosis, our findings demonstrate that MMAR_2894 may contribute to a species-specific function of the ESX-1 system in M. marinum, providing new insight into how the M. marinum and M. tuberculosis systems differ." @default.
• W2919212908 created "2019-03-11" @default.
• W2919212908 creator A5061523117 @default.
• W2919212908 creator A5063371809 @default.
• W2919212908 creator A5071551590 @default.
• W2919212908 creator A5085814147 @default.
• W2919212908 date "2019-07-15" @default.
• W2919212908 modified "2023-10-16" @default.
• W2919212908 title "A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis" @default.
• W2919212908 cites W1506741363 @default.
• W2919212908 cites W1508212288 @default.
• W2919212908 cites W1551684330 @default.
• W2919212908 cites W1553697637 @default.
• W2919212908 cites W1576093496 @default.
• W2919212908 cites W1845511907 @default.
• W2919212908 cites W1940294549 @default.
• W2919212908 cites W1970650210 @default.
• W2919212908 cites W1974305305 @default.
• W2919212908 cites W1974667981 @default.
• W2919212908 cites W1974995346 @default.
• W2919212908 cites W1983828601 @default.
• W2919212908 cites W1984355221 @default.
• W2919212908 cites W1993796017 @default.
• W2919212908 cites W2018937143 @default.
• W2919212908 cites W2023008751 @default.
• W2919212908 cites W2023874344 @default.
• W2919212908 cites W2025187029 @default.
• W2919212908 cites W2036321220 @default.
• W2919212908 cites W2036635548 @default.
• W2919212908 cites W2039288267 @default.
• W2919212908 cites W2040558306 @default.
• W2919212908 cites W2043595421 @default.
• W2919212908 cites W2046091124 @default.
• W2919212908 cites W2049312907 @default.
• W2919212908 cites W2051792510 @default.
• W2919212908 cites W2057740405 @default.
• W2919212908 cites W2058677329 @default.
• W2919212908 cites W2065027419 @default.
• W2919212908 cites W2066545380 @default.
• W2919212908 cites W2070413611 @default.
• W2919212908 cites W2077700749 @default.
• W2919212908 cites W2080308390 @default.
• W2919212908 cites W2081816898 @default.
• W2919212908 cites W2086227247 @default.
• W2919212908 cites W2097481253 @default.
• W2919212908 cites W2097803859 @default.
• W2919212908 cites W2098107406 @default.
• W2919212908 cites W2101358576 @default.
• W2919212908 cites W2104415540 @default.
• W2919212908 cites W2107314371 @default.
• W2919212908 cites W2107552777 @default.
• W2919212908 cites W2107983230 @default.
• W2919212908 cites W2108256296 @default.
• W2919212908 cites W2111068567 @default.
• W2919212908 cites W2111176609 @default.
• W2919212908 cites W2121449107 @default.
• W2919212908 cites W2123266729 @default.
• W2919212908 cites W2125643362 @default.
• W2919212908 cites W2129267752 @default.
• W2919212908 cites W2135116662 @default.
• W2919212908 cites W2135524542 @default.
• W2919212908 cites W2141681443 @default.
• W2919212908 cites W2142410038 @default.
• W2919212908 cites W2143061508 @default.
• W2919212908 cites W2148157651 @default.
• W2919212908 cites W2152561081 @default.
• W2919212908 cites W2154293774 @default.
• W2919212908 cites W2162267457 @default.
• W2919212908 cites W2168832175 @default.
• W2919212908 cites W2169882798 @default.
• W2919212908 cites W2170776626 @default.
• W2919212908 cites W2225338927 @default.
• W2919212908 cites W2283857467 @default.
• W2919212908 cites W2332848608 @default.
• W2919212908 cites W2333939089 @default.
• W2919212908 cites W2345284488 @default.
• W2919212908 cites W2413218470 @default.
• W2919212908 cites W2463195069 @default.
• W2919212908 cites W2520937659 @default.
• W2919212908 cites W2527411440 @default.
• W2919212908 cites W2551199765 @default.
• W2919212908 cites W2557434146 @default.
• W2919212908 cites W2560390108 @default.
• W2919212908 cites W2581461126 @default.
• W2919212908 cites W2588820084 @default.
• W2919212908 cites W2600474991 @default.
• W2919212908 cites W2608522697 @default.
• W2919212908 cites W2611319530 @default.
• W2919212908 cites W2614148745 @default.
• W2919212908 cites W2767640841 @default.
• W2919212908 cites W2768447667 @default.
• W2919212908 cites W2784014905 @default.
• W2919212908 cites W2796219067 @default.
• W2919212908 cites W2797949377 @default.
• W2919212908 cites W2801475204 @default.
• W2919212908 cites W2802668680 @default.
• W2919212908 cites W2802939794 @default.
• W2919212908 cites W2883858324 @default.
• W2919212908 cites W2886036129 @default.
• W2919212908 cites W2887138770 @default.

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