FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919253225> ?p ?o ?g. }

• W2919253225 endingPage "602" @default.
• W2919253225 startingPage "599" @default.
• W2919253225 abstract "A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Herein, we report that esterification of the carboxyl groups of an enzyme with a diazo compound enables not only its passage into the cytosol but also the retention of its catalytic activity there. This scenario is demonstrated with human ribonuclease 1, which manifests ribonucleolytic activity that can be cytotoxic. After internalization, the nascent esters are hydrolyzed in situ by endogenous esterases, making the process traceless. This strategy provides unprecedented opportunities for the delivery of functional enzymes into human cells." @default.
• W2919253225 created "2019-03-11" @default.
• W2919253225 creator A5014656935 @default.
• W2919253225 creator A5063115585 @default.
• W2919253225 creator A5075110935 @default.
• W2919253225 date "2019-03-04" @default.
• W2919253225 modified "2023-09-30" @default.
• W2919253225 title "Esterification Delivers a Functional Enzyme into a Human Cell" @default.
• W2919253225 cites W1519297291 @default.
• W2919253225 cites W1966535097 @default.
• W2919253225 cites W1984548348 @default.
• W2919253225 cites W1987929665 @default.
• W2919253225 cites W1990436439 @default.
• W2919253225 cites W1991269320 @default.
• W2919253225 cites W1996050139 @default.
• W2919253225 cites W1997876444 @default.
• W2919253225 cites W1998745985 @default.
• W2919253225 cites W2011831437 @default.
• W2919253225 cites W2021420392 @default.
• W2919253225 cites W2030836217 @default.
• W2919253225 cites W2034517648 @default.
• W2919253225 cites W2036911034 @default.
• W2919253225 cites W2059142487 @default.
• W2919253225 cites W2061976424 @default.
• W2919253225 cites W2086928290 @default.
• W2919253225 cites W2104111419 @default.
• W2919253225 cites W2118731546 @default.
• W2919253225 cites W2121158677 @default.
• W2919253225 cites W2141296897 @default.
• W2919253225 cites W2175408680 @default.
• W2919253225 cites W2323367853 @default.
• W2919253225 cites W2330923532 @default.
• W2919253225 cites W2547372962 @default.
• W2919253225 cites W2560154437 @default.
• W2919253225 cites W2745164897 @default.
• W2919253225 cites W2763313852 @default.
• W2919253225 cites W2786536332 @default.
• W2919253225 cites W2810653208 @default.
• W2919253225 cites W2895260699 @default.
• W2919253225 cites W2898750930 @default.
• W2919253225 cites W2918095064 @default.
• W2919253225 cites W2961250170 @default.
• W2919253225 cites W4234944446 @default.
• W2919253225 doi "https://doi.org/10.1021/acschembio.9b00033" @default.
• W2919253225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6474803" @default.
• W2919253225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30830748" @default.
• W2919253225 hasPublicationYear "2019" @default.
• W2919253225 type Work @default.
• W2919253225 sameAs 2919253225 @default.
• W2919253225 citedByCount "27" @default.
• W2919253225 countsByYear W29192532252019 @default.
• W2919253225 countsByYear W29192532252020 @default.
• W2919253225 countsByYear W29192532252021 @default.
• W2919253225 countsByYear W29192532252022 @default.
• W2919253225 countsByYear W29192532252023 @default.
• W2919253225 crossrefType "journal-article" @default.
• W2919253225 hasAuthorship W2919253225A5014656935 @default.
• W2919253225 hasAuthorship W2919253225A5063115585 @default.
• W2919253225 hasAuthorship W2919253225A5075110935 @default.
• W2919253225 hasBestOaLocation W29192532252 @default.
• W2919253225 hasConcept C104317684 @default.
• W2919253225 hasConcept C10879258 @default.
• W2919253225 hasConcept C139770010 @default.
• W2919253225 hasConcept C1491633281 @default.
• W2919253225 hasConcept C155647269 @default.
• W2919253225 hasConcept C171852809 @default.
• W2919253225 hasConcept C181199279 @default.
• W2919253225 hasConcept C185592680 @default.
• W2919253225 hasConcept C2776904781 @default.
• W2919253225 hasConcept C2778976237 @default.
• W2919253225 hasConcept C55493867 @default.
• W2919253225 hasConcept C67705224 @default.
• W2919253225 hasConcept C86803240 @default.
• W2919253225 hasConcept C94412978 @default.
• W2919253225 hasConcept C95444343 @default.
• W2919253225 hasConcept C98539663 @default.
• W2919253225 hasConceptScore W2919253225C104317684 @default.
• W2919253225 hasConceptScore W2919253225C10879258 @default.
• W2919253225 hasConceptScore W2919253225C139770010 @default.
• W2919253225 hasConceptScore W2919253225C1491633281 @default.
• W2919253225 hasConceptScore W2919253225C155647269 @default.
• W2919253225 hasConceptScore W2919253225C171852809 @default.
• W2919253225 hasConceptScore W2919253225C181199279 @default.
• W2919253225 hasConceptScore W2919253225C185592680 @default.
• W2919253225 hasConceptScore W2919253225C2776904781 @default.
• W2919253225 hasConceptScore W2919253225C2778976237 @default.
• W2919253225 hasConceptScore W2919253225C55493867 @default.
• W2919253225 hasConceptScore W2919253225C67705224 @default.
• W2919253225 hasConceptScore W2919253225C86803240 @default.
• W2919253225 hasConceptScore W2919253225C94412978 @default.
• W2919253225 hasConceptScore W2919253225C95444343 @default.
• W2919253225 hasConceptScore W2919253225C98539663 @default.
• W2919253225 hasFunder F4320314070 @default.
• W2919253225 hasFunder F4320337351 @default.
• W2919253225 hasFunder F4320337354 @default.
• W2919253225 hasIssue "4" @default.
• W2919253225 hasLocation W29192532251 @default.
• W2919253225 hasLocation W29192532252 @default.

• next