FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919299387> ?p ?o ?g. }

• W2919299387 abstract "Abstract Erythropoiesis has been extensively studied using in vitro and in vivo animal models. Despite this, there is still limited data about the gene expression profiles (GEP) of primary (ex vivo) normal human bone marrow (BM) erythroid maturation. We investigated the GEP of nucleated red blood cell (NRBC) precursors during normal human BM erythropoiesis. Three maturation-associated populations of NRBC were identified and purified from (fresh) normal human BM by flow cytometry and the GEP of each purified cell population directly analyzed using DNA-oligonucleotide microarrays. Overall, 6569 genes (19% of the genes investigated) were expressed in ≥1 stage of BM erythropoiesis at stable (e.g., genes involved in DNA process, cell signaling, protein organization and hemoglobin production) or variable amounts (e.g., genes related to cell differentiation, apoptosis, metabolism), the latter showing a tendency to either decrease from stage 1 to 3 (genes associated with regulation of erythroid differentiation and survival, e.g., SPI1 , STAT5A ) or increase from stage 2 to stage 3 (genes associated with autophagy, erythroid functions such as heme production, e.g., ALAS1 , ALAS2), iron metabolism (e.g., ISCA1, SLC11A2 ), protection from oxidative stress (e.g., UCP2 , PARK7 ), and NRBC enucleation (e.g., ID2 , RB1 ). Interestingly, genes involved in apoptosis (e.g., CASP8, P2RX1 ) and immune response (e.g., FOXO3, TRAF6 ) were also upregulated in the last stage (stage 3) of maturation of NRBC precursors. Our results confirm and extend on previous observations and providing a frame of reference for better understanding the critical steps of human erythroid maturation and its potential alteration in patients with different clonal and non-clonal erythropoietic disorders." @default.
• W2919299387 created "2019-03-11" @default.
• W2919299387 creator A5011977184 @default.
• W2919299387 creator A5028824291 @default.
• W2919299387 creator A5029900948 @default.
• W2919299387 creator A5034728534 @default.
• W2919299387 creator A5051937379 @default.
• W2919299387 creator A5055210686 @default.
• W2919299387 creator A5056586454 @default.
• W2919299387 creator A5056748930 @default.
• W2919299387 creator A5068688043 @default.
• W2919299387 creator A5079610591 @default.
• W2919299387 date "2019-02-28" @default.
• W2919299387 modified "2023-10-09" @default.
• W2919299387 title "Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis" @default.
• W2919299387 cites W149801576 @default.
• W2919299387 cites W1504660023 @default.
• W2919299387 cites W1963516841 @default.
• W2919299387 cites W1968628080 @default.
• W2919299387 cites W1972140920 @default.
• W2919299387 cites W1972927903 @default.
• W2919299387 cites W1993950505 @default.
• W2919299387 cites W1995773059 @default.
• W2919299387 cites W2008289687 @default.
• W2919299387 cites W2008757142 @default.
• W2919299387 cites W2009869123 @default.
• W2919299387 cites W2015455520 @default.
• W2919299387 cites W2016913555 @default.
• W2919299387 cites W2018235438 @default.
• W2919299387 cites W2023455124 @default.
• W2919299387 cites W2034914128 @default.
• W2919299387 cites W2040662831 @default.
• W2919299387 cites W2044354693 @default.
• W2919299387 cites W2044613411 @default.
• W2919299387 cites W2044970136 @default.
• W2919299387 cites W2061603378 @default.
• W2919299387 cites W2084988418 @default.
• W2919299387 cites W2086844955 @default.
• W2919299387 cites W2090630520 @default.
• W2919299387 cites W2090817847 @default.
• W2919299387 cites W2091333494 @default.
• W2919299387 cites W2091571816 @default.
• W2919299387 cites W2096040928 @default.
• W2919299387 cites W2097006689 @default.
• W2919299387 cites W2100681150 @default.
• W2919299387 cites W2102614122 @default.
• W2919299387 cites W2113432343 @default.
• W2919299387 cites W2118644071 @default.
• W2919299387 cites W2121898643 @default.
• W2919299387 cites W2123705280 @default.
• W2919299387 cites W2129929756 @default.
• W2919299387 cites W2130410032 @default.
• W2919299387 cites W2132492733 @default.
• W2919299387 cites W2133952097 @default.
• W2919299387 cites W2138600828 @default.
• W2919299387 cites W2139655181 @default.
• W2919299387 cites W2140378965 @default.
• W2919299387 cites W2140717627 @default.
• W2919299387 cites W2145527883 @default.
• W2919299387 cites W2162198627 @default.
• W2919299387 cites W2165700886 @default.
• W2919299387 cites W2174761822 @default.
• W2919299387 cites W2357596453 @default.
• W2919299387 cites W2480195390 @default.
• W2919299387 cites W2504220050 @default.
• W2919299387 cites W2518431929 @default.
• W2919299387 cites W3719606 @default.
• W2919299387 cites W4254878650 @default.
• W2919299387 cites W77625167 @default.
• W2919299387 doi "https://doi.org/10.1038/s41420-019-0151-0" @default.
• W2919299387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6395734" @default.
• W2919299387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30854228" @default.
• W2919299387 hasPublicationYear "2019" @default.
• W2919299387 type Work @default.
• W2919299387 sameAs 2919299387 @default.
• W2919299387 citedByCount "26" @default.
• W2919299387 countsByYear W29192993872020 @default.
• W2919299387 countsByYear W29192993872021 @default.
• W2919299387 countsByYear W29192993872022 @default.
• W2919299387 countsByYear W29192993872023 @default.
• W2919299387 crossrefType "journal-article" @default.
• W2919299387 hasAuthorship W2919299387A5011977184 @default.
• W2919299387 hasAuthorship W2919299387A5028824291 @default.
• W2919299387 hasAuthorship W2919299387A5029900948 @default.
• W2919299387 hasAuthorship W2919299387A5034728534 @default.
• W2919299387 hasAuthorship W2919299387A5051937379 @default.
• W2919299387 hasAuthorship W2919299387A5055210686 @default.
• W2919299387 hasAuthorship W2919299387A5056586454 @default.
• W2919299387 hasAuthorship W2919299387A5056748930 @default.
• W2919299387 hasAuthorship W2919299387A5068688043 @default.
• W2919299387 hasAuthorship W2919299387A5079610591 @default.
• W2919299387 hasBestOaLocation W29192993871 @default.
• W2919299387 hasConcept C126322002 @default.
• W2919299387 hasConcept C144024400 @default.
• W2919299387 hasConcept C149923435 @default.
• W2919299387 hasConcept C153911025 @default.
• W2919299387 hasConcept C203014093 @default.
• W2919299387 hasConcept C2778248108 @default.
• W2919299387 hasConcept C2779703530 @default.
• W2919299387 hasConcept C2780007613 @default.

• next