FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919333179> ?p ?o ?g. }

• W2919333179 endingPage "e11942" @default.
• W2919333179 startingPage "e11942" @default.
• W2919333179 abstract "Heart failure with preserved ejection fraction (HFpEF) is a common syndrome, accounting for more than one half of all heart failure patients, which is associated with high morbidity and mortality. But there is little evidence-based therapeutic strategies for the management of HFpEF. Previous studies reported the effects of spironolactone on HFpEF; however, the results were inconsistent. In this meta-analysis, we evaluated the effects of spironolactone on HFpEF.Articles were searched on PubMed, EMBASE, and COCHRANE databases before May, 2017, and were supplemented by hand searches of reference lists of included studies and review articles. Eligible articles were restricted to randomized controlled trials (RCTs). The odds ratios (ORs) of the dichotomous data, mean difference (MD) of continuous data, and 95% confidence intervals (CIs) were calculated to assess the effects of spironolactone in patients with HFpEF.A total of 7 studies including 4147 participants were analyzed. There were significant improvements on the E/e' index (MD -1.38; 95% CI, -2.03 to -0.73; P < .0001) and E/A velocity ratio (MD -0.05; 95% CI, -0.10 to -0.00; P = .03) under spironolactone treatment compared with placebo, while there was no effect on the deceleration time (MD 1.04; 95% CI, -8.27 to 10.35; P = .83). Subgroup analyses on the E/A velocity ratio showed that there was obvious benefit from spironolactone therapy in patients with follow-up periods >6 months but not in those with follow-up periods ≤6 months. There was no reduction in all-cause mortality and hospitalization compared with placebo. And no improvement in 6-minute walk distance was seen compared with placebo.This meta-analysis demonstrates that the use of spironolactone improves left ventricular diastolic function in patients with HFpEF, whereas it has no effect on all-cause mortality and hospitalization, and the 6-minute walk distance. Further larger size, multicenter, RCTs are required to confirm the effects of spironolactone on patients with HFpEF." @default.
• W2919333179 created "2019-03-11" @default.
• W2919333179 creator A5003105409 @default.
• W2919333179 creator A5007704446 @default.
• W2919333179 creator A5041674277 @default.
• W2919333179 creator A5049895313 @default.
• W2919333179 creator A5052844169 @default.
• W2919333179 creator A5053387271 @default.
• W2919333179 creator A5065912071 @default.
• W2919333179 creator A5074146802 @default.
• W2919333179 creator A5076092727 @default.
• W2919333179 date "2018-08-01" @default.
• W2919333179 modified "2023-09-23" @default.
• W2919333179 title "Effects of spironolactone in heart failure with preserved ejection fraction" @default.
• W2919333179 cites W1180376944 @default.
• W2919333179 cites W1262222358 @default.
• W2919333179 cites W1418928096 @default.
• W2919333179 cites W1818378016 @default.
• W2919333179 cites W1853593184 @default.
• W2919333179 cites W1883738259 @default.
• W2919333179 cites W1983102904 @default.
• W2919333179 cites W1990960573 @default.
• W2919333179 cites W1999321766 @default.
• W2919333179 cites W2000016920 @default.
• W2919333179 cites W2028991902 @default.
• W2919333179 cites W2038163008 @default.
• W2919333179 cites W2047031218 @default.
• W2919333179 cites W2067956701 @default.
• W2919333179 cites W2089110945 @default.
• W2919333179 cites W2098767714 @default.
• W2919333179 cites W2102779499 @default.
• W2919333179 cites W2104209472 @default.
• W2919333179 cites W2106516266 @default.
• W2919333179 cites W2106909429 @default.
• W2919333179 cites W2107604758 @default.
• W2919333179 cites W2111693655 @default.
• W2919333179 cites W2113829060 @default.
• W2919333179 cites W2131184290 @default.
• W2919333179 cites W2152072062 @default.
• W2919333179 cites W2156098321 @default.
• W2919333179 cites W2159549492 @default.
• W2919333179 cites W2313186535 @default.
• W2919333179 cites W2408444136 @default.
• W2919333179 cites W2427094903 @default.
• W2919333179 cites W246286872 @default.
• W2919333179 cites W2485135212 @default.
• W2919333179 cites W2539412725 @default.
• W2919333179 cites W2546210019 @default.
• W2919333179 cites W2554029516 @default.
• W2919333179 cites W2605384071 @default.
• W2919333179 cites W2609605008 @default.
• W2919333179 cites W2614496641 @default.
• W2919333179 cites W2621310086 @default.
• W2919333179 cites W4238907867 @default.
• W2919333179 cites W4294215472 @default.
• W2919333179 doi "https://doi.org/10.1097/md.0000000000011942" @default.
• W2919333179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6392615" @default.
• W2919333179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30170387" @default.
• W2919333179 hasPublicationYear "2018" @default.
• W2919333179 type Work @default.
• W2919333179 sameAs 2919333179 @default.
• W2919333179 citedByCount "14" @default.
• W2919333179 countsByYear W29193331792019 @default.
• W2919333179 countsByYear W29193331792020 @default.
• W2919333179 countsByYear W29193331792021 @default.
• W2919333179 countsByYear W29193331792022 @default.
• W2919333179 countsByYear W29193331792023 @default.
• W2919333179 crossrefType "journal-article" @default.
• W2919333179 hasAuthorship W2919333179A5003105409 @default.
• W2919333179 hasAuthorship W2919333179A5007704446 @default.
• W2919333179 hasAuthorship W2919333179A5041674277 @default.
• W2919333179 hasAuthorship W2919333179A5049895313 @default.
• W2919333179 hasAuthorship W2919333179A5052844169 @default.
• W2919333179 hasAuthorship W2919333179A5053387271 @default.
• W2919333179 hasAuthorship W2919333179A5065912071 @default.
• W2919333179 hasAuthorship W2919333179A5074146802 @default.
• W2919333179 hasAuthorship W2919333179A5076092727 @default.
• W2919333179 hasBestOaLocation W29193331791 @default.
• W2919333179 hasConcept C126322002 @default.
• W2919333179 hasConcept C142724271 @default.
• W2919333179 hasConcept C156957248 @default.
• W2919333179 hasConcept C164705383 @default.
• W2919333179 hasConcept C168563851 @default.
• W2919333179 hasConcept C204787440 @default.
• W2919333179 hasConcept C27081682 @default.
• W2919333179 hasConcept C2776379505 @default.
• W2919333179 hasConcept C2777099384 @default.
• W2919333179 hasConcept C2778198053 @default.
• W2919333179 hasConcept C44249647 @default.
• W2919333179 hasConcept C71924100 @default.
• W2919333179 hasConcept C78085059 @default.
• W2919333179 hasConcept C95190672 @default.
• W2919333179 hasConceptScore W2919333179C126322002 @default.
• W2919333179 hasConceptScore W2919333179C142724271 @default.
• W2919333179 hasConceptScore W2919333179C156957248 @default.
• W2919333179 hasConceptScore W2919333179C164705383 @default.
• W2919333179 hasConceptScore W2919333179C168563851 @default.
• W2919333179 hasConceptScore W2919333179C204787440 @default.

• next