Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919367648> ?p ?o ?g. }
- W2919367648 endingPage "292" @default.
- W2919367648 startingPage "292" @default.
- W2919367648 abstract "Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1–4) and five ligands (Dll1-3–4, Jagged1–2) that mainly contribute to the development and maintenance of the central nervous system (CNS). Neural stem cells (NSCs) are the starting point for neurogenesis and other neurological functions, representing an essential aspect for the homeostasis of the CNS. Therefore, genetic and functional alterations to NSCs can lead to the development of brain tumors, including glioblastoma multiforme (GBM). GBM remains an incurable disease, and the reason for the failure of current therapies and tumor relapse is the presence of a small subpopulation of tumor cells known as glioma stem cells (GSCs), characterized by their stem cell-like properties and aggressive phenotype. Growing evidence reveals that Notch signaling is highly active in GSCs, where it suppresses differentiation and maintains stem-like properties, contributing to GBM tumorigenesis and conventional-treatment resistance. In this review, we try to give a comprehensive view of the contribution of Notch signaling to GBM and its possible implication as a target for new therapeutic approaches." @default.
- W2919367648 created "2019-03-11" @default.
- W2919367648 creator A5036746185 @default.
- W2919367648 creator A5063615908 @default.
- W2919367648 date "2019-03-01" @default.
- W2919367648 modified "2023-10-12" @default.
- W2919367648 title "Role of Notch Signaling Pathway in Glioblastoma Multiforme Pathogenesis" @default.
- W2919367648 cites W1500946936 @default.
- W2919367648 cites W1508615665 @default.
- W2919367648 cites W1542937136 @default.
- W2919367648 cites W1675105744 @default.
- W2919367648 cites W1680693606 @default.
- W2919367648 cites W1756165953 @default.
- W2919367648 cites W1890846155 @default.
- W2919367648 cites W1899815911 @default.
- W2919367648 cites W1916309376 @default.
- W2919367648 cites W1937989435 @default.
- W2919367648 cites W1965195624 @default.
- W2919367648 cites W1966287338 @default.
- W2919367648 cites W1971329509 @default.
- W2919367648 cites W1971571526 @default.
- W2919367648 cites W1972496597 @default.
- W2919367648 cites W1972700706 @default.
- W2919367648 cites W1973569665 @default.
- W2919367648 cites W1973605716 @default.
- W2919367648 cites W1975365481 @default.
- W2919367648 cites W1977986556 @default.
- W2919367648 cites W1982831729 @default.
- W2919367648 cites W1984059331 @default.
- W2919367648 cites W1984475127 @default.
- W2919367648 cites W1984610351 @default.
- W2919367648 cites W1987582818 @default.
- W2919367648 cites W1987857383 @default.
- W2919367648 cites W1994901446 @default.
- W2919367648 cites W1995181458 @default.
- W2919367648 cites W1996816592 @default.
- W2919367648 cites W1997801717 @default.
- W2919367648 cites W1998941426 @default.
- W2919367648 cites W2000078674 @default.
- W2919367648 cites W2001029428 @default.
- W2919367648 cites W2001845064 @default.
- W2919367648 cites W2003438982 @default.
- W2919367648 cites W2004423242 @default.
- W2919367648 cites W2006387377 @default.
- W2919367648 cites W2006898444 @default.
- W2919367648 cites W2007904774 @default.
- W2919367648 cites W2009702490 @default.
- W2919367648 cites W2015100090 @default.
- W2919367648 cites W2015346961 @default.
- W2919367648 cites W2015610520 @default.
- W2919367648 cites W2017559288 @default.
- W2919367648 cites W2018607339 @default.
- W2919367648 cites W2018868898 @default.
- W2919367648 cites W2019484386 @default.
- W2919367648 cites W2019708706 @default.
- W2919367648 cites W2020295576 @default.
- W2919367648 cites W2022400819 @default.
- W2919367648 cites W2022822197 @default.
- W2919367648 cites W2022976025 @default.
- W2919367648 cites W2023532816 @default.
- W2919367648 cites W2024370135 @default.
- W2919367648 cites W2024837427 @default.
- W2919367648 cites W2025748388 @default.
- W2919367648 cites W2028794212 @default.
- W2919367648 cites W2028916975 @default.
- W2919367648 cites W2030924655 @default.
- W2919367648 cites W2039842506 @default.
- W2919367648 cites W2040113269 @default.
- W2919367648 cites W2040458067 @default.
- W2919367648 cites W2040538271 @default.
- W2919367648 cites W2046543182 @default.
- W2919367648 cites W2050951687 @default.
- W2919367648 cites W2052334769 @default.
- W2919367648 cites W2053056402 @default.
- W2919367648 cites W2053510513 @default.
- W2919367648 cites W2055468924 @default.
- W2919367648 cites W2055556917 @default.
- W2919367648 cites W2056146179 @default.
- W2919367648 cites W2058733797 @default.
- W2919367648 cites W2059975046 @default.
- W2919367648 cites W2065510014 @default.
- W2919367648 cites W2065569210 @default.
- W2919367648 cites W2078717028 @default.
- W2919367648 cites W2082195162 @default.
- W2919367648 cites W2082409875 @default.
- W2919367648 cites W2083098015 @default.
- W2919367648 cites W2083425643 @default.
- W2919367648 cites W2085541301 @default.
- W2919367648 cites W2086477105 @default.
- W2919367648 cites W2088906043 @default.
- W2919367648 cites W2090263169 @default.
- W2919367648 cites W2091022798 @default.
- W2919367648 cites W2093364931 @default.
- W2919367648 cites W2095032355 @default.
- W2919367648 cites W2096539796 @default.
- W2919367648 cites W2098503611 @default.
- W2919367648 cites W2099023875 @default.
- W2919367648 cites W2100111497 @default.