Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919378364> ?p ?o ?g. }
- W2919378364 abstract "Abstract Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therapy, yet the functional consequences of these division modes remain to be determined. Using a fluorescent reporter for cell surface receptor distribution during mitosis, we found that ACD in glioblastoma CSCs generated a daughter cell with enhanced therapeutic resistance and increased co-inheritance of epidermal growth factor receptor (EGFR) and neurotrophin receptor (p75NTR). Stimulation of both receptors maintained self-renewal under differentiation conditions. While p75NTR knockdown did not compromise CSC maintenance, therapeutic efficacy of EGFR inhibition was enhanced, indicating that co-inheritance of p75NTR and EGFR promotes resistance to EGFR inhibition through a redundant mechanism. These data demonstrate that ACD produces progeny with co-enriched growth factor receptors, which contributes to the generation of a more therapeutically resistant CSC population. Graphical abstract" @default.
- W2919378364 created "2019-03-11" @default.
- W2919378364 creator A5000064419 @default.
- W2919378364 creator A5000089514 @default.
- W2919378364 creator A5004589257 @default.
- W2919378364 creator A5007495491 @default.
- W2919378364 creator A5013023933 @default.
- W2919378364 creator A5023573690 @default.
- W2919378364 creator A5030372369 @default.
- W2919378364 creator A5041530623 @default.
- W2919378364 creator A5090255208 @default.
- W2919378364 date "2019-03-06" @default.
- W2919378364 modified "2023-09-28" @default.
- W2919378364 title "Asymmetric Division Promotes Therapeutic Resistance in Glioblastoma Stem Cells" @default.
- W2919378364 cites W1540671324 @default.
- W2919378364 cites W1564861448 @default.
- W2919378364 cites W1891848729 @default.
- W2919378364 cites W1974562193 @default.
- W2919378364 cites W1982831729 @default.
- W2919378364 cites W1989546349 @default.
- W2919378364 cites W1992514491 @default.
- W2919378364 cites W2009031936 @default.
- W2919378364 cites W2013875639 @default.
- W2919378364 cites W2030017878 @default.
- W2919378364 cites W2030794991 @default.
- W2919378364 cites W2039753443 @default.
- W2919378364 cites W2060551076 @default.
- W2919378364 cites W2063087840 @default.
- W2919378364 cites W2064717645 @default.
- W2919378364 cites W2080899976 @default.
- W2919378364 cites W2086216067 @default.
- W2919378364 cites W2088813072 @default.
- W2919378364 cites W2097125495 @default.
- W2919378364 cites W2127792983 @default.
- W2919378364 cites W2135298618 @default.
- W2919378364 cites W2135925682 @default.
- W2919378364 cites W2153051750 @default.
- W2919378364 cites W2156367614 @default.
- W2919378364 cites W2164675211 @default.
- W2919378364 cites W2166476411 @default.
- W2919378364 cites W2168805837 @default.
- W2919378364 cites W2273006669 @default.
- W2919378364 cites W2275529157 @default.
- W2919378364 cites W2294834029 @default.
- W2919378364 cites W2312738416 @default.
- W2919378364 cites W2337546159 @default.
- W2919378364 cites W2338169771 @default.
- W2919378364 cites W2585659713 @default.
- W2919378364 cites W2607167117 @default.
- W2919378364 cites W2763367287 @default.
- W2919378364 cites W2777704960 @default.
- W2919378364 cites W2786235809 @default.
- W2919378364 cites W2796407886 @default.
- W2919378364 cites W2800929090 @default.
- W2919378364 cites W2808491310 @default.
- W2919378364 cites W2884330478 @default.
- W2919378364 cites W2891125665 @default.
- W2919378364 cites W2907617661 @default.
- W2919378364 cites W2951779355 @default.
- W2919378364 doi "https://doi.org/10.1101/569962" @default.
- W2919378364 hasPublicationYear "2019" @default.
- W2919378364 type Work @default.
- W2919378364 sameAs 2919378364 @default.
- W2919378364 citedByCount "0" @default.
- W2919378364 crossrefType "posted-content" @default.
- W2919378364 hasAuthorship W2919378364A5000064419 @default.
- W2919378364 hasAuthorship W2919378364A5000089514 @default.
- W2919378364 hasAuthorship W2919378364A5004589257 @default.
- W2919378364 hasAuthorship W2919378364A5007495491 @default.
- W2919378364 hasAuthorship W2919378364A5013023933 @default.
- W2919378364 hasAuthorship W2919378364A5023573690 @default.
- W2919378364 hasAuthorship W2919378364A5030372369 @default.
- W2919378364 hasAuthorship W2919378364A5041530623 @default.
- W2919378364 hasAuthorship W2919378364A5090255208 @default.
- W2919378364 hasBestOaLocation W29193783641 @default.
- W2919378364 hasConcept C108636557 @default.
- W2919378364 hasConcept C1491633281 @default.
- W2919378364 hasConcept C170493617 @default.
- W2919378364 hasConcept C185592680 @default.
- W2919378364 hasConcept C2776362946 @default.
- W2919378364 hasConcept C2778977658 @default.
- W2919378364 hasConcept C2779438470 @default.
- W2919378364 hasConcept C28328180 @default.
- W2919378364 hasConcept C2908647359 @default.
- W2919378364 hasConcept C502942594 @default.
- W2919378364 hasConcept C54355233 @default.
- W2919378364 hasConcept C71924100 @default.
- W2919378364 hasConcept C85813293 @default.
- W2919378364 hasConcept C86803240 @default.
- W2919378364 hasConcept C93304396 @default.
- W2919378364 hasConcept C95444343 @default.
- W2919378364 hasConcept C99454951 @default.
- W2919378364 hasConceptScore W2919378364C108636557 @default.
- W2919378364 hasConceptScore W2919378364C1491633281 @default.
- W2919378364 hasConceptScore W2919378364C170493617 @default.
- W2919378364 hasConceptScore W2919378364C185592680 @default.
- W2919378364 hasConceptScore W2919378364C2776362946 @default.
- W2919378364 hasConceptScore W2919378364C2778977658 @default.
- W2919378364 hasConceptScore W2919378364C2779438470 @default.
- W2919378364 hasConceptScore W2919378364C28328180 @default.