FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919467874> ?p ?o ?g. }

• W2919467874 endingPage "2852" @default.
• W2919467874 startingPage "2841" @default.
• W2919467874 abstract "Contractility of lymphatic collectors is essential for the functionality of the lymphatic system and, thus, for lymph flow. Previously published rates of lymphatic collectors in mice vary from 1.1 to 17 contractions/min with little agreement between investigators. In this study, we focused on the effects of different anaesthesia regimens on lymphatic vessel contractility using in vivo imaging approaches. We show that isoflurane and pentobarbital have an inhibitory effect on lymphatic contractility compared to mice under other anaesthesia regimens and in awake conditions. These results should help to establish a standardization of lymphatic contraction studies in mice and may also have relevance for patients undergoing anaesthesia during surgery.Contractions of collecting lymphatic vessels are essential for the function of the lymphatic vascular system, due to the lack of a central pump to drive flow. A wide range of physiological contraction frequencies and strengths have been reported in previous in vivo studies in mice. This is probably due to the different types of anaesthesia that have been used and which might have exerted direct influences on lymphatic vessel function. We investigated six commonly used anaesthesia regimens for their influence on lymphatic vessel contractility using near-infrared in vivo imaging approaches. Non-invasive imaging of the lymphatic leg collector revealed distinct effects of the anaesthesia regimens with reduced contraction activity under isoflurane and pentobarbital anaesthesia. Isoflurane also reduced the contractility of near-infrared dye-loaded vessels during invasive imaging of the lymphatic flank collector whereas the combination of ketamine/xylazine/acepromazine had no major effects. The transport time of a lymphatic-specific dye from the skin through the lymphatic vasculature to the systemic bloodstream was also delayed under isoflurane anaesthesia. Based on these results, we recommend use of combinations of ketamine and medetomidine for future non-invasive studies and of ketamine, xylazine and acepromazine for invasive studies. Beyond their importance for facilitating the interpretation and planning of animal studies, our findings might also have relevance for human patients undergoing anaesthesia for surgical procedures." @default.
• W2919467874 created "2019-03-11" @default.
• W2919467874 creator A5015396887 @default.
• W2919467874 creator A5041603810 @default.
• W2919467874 creator A5045487548 @default.
• W2919467874 creator A5046877063 @default.
• W2919467874 creator A5060019261 @default.
• W2919467874 date "2019-03-20" @default.
• W2919467874 modified "2023-10-16" @default.
• W2919467874 title "Differential effects of anaesthesia on the contractility of lymphatic vessels <i>in vivo</i>" @default.
• W2919467874 cites W1965780190 @default.
• W2919467874 cites W1968237864 @default.
• W2919467874 cites W1975378905 @default.
• W2919467874 cites W1979966263 @default.
• W2919467874 cites W1980212519 @default.
• W2919467874 cites W1987027870 @default.
• W2919467874 cites W1988966991 @default.
• W2919467874 cites W1989443288 @default.
• W2919467874 cites W1990423860 @default.
• W2919467874 cites W2003390250 @default.
• W2919467874 cites W2006912346 @default.
• W2919467874 cites W2040654453 @default.
• W2919467874 cites W2043984617 @default.
• W2919467874 cites W2059164493 @default.
• W2919467874 cites W2069689051 @default.
• W2919467874 cites W2084085941 @default.
• W2919467874 cites W2098387869 @default.
• W2919467874 cites W2109049790 @default.
• W2919467874 cites W2115392273 @default.
• W2919467874 cites W2117107881 @default.
• W2919467874 cites W2123455744 @default.
• W2919467874 cites W2132454600 @default.
• W2919467874 cites W2139946024 @default.
• W2919467874 cites W2166161383 @default.
• W2919467874 cites W2290613020 @default.
• W2919467874 cites W2295076201 @default.
• W2919467874 cites W2318724838 @default.
• W2919467874 cites W2395338705 @default.
• W2919467874 cites W2399450046 @default.
• W2919467874 cites W2576017616 @default.
• W2919467874 cites W2784890959 @default.
• W2919467874 cites W871185489 @default.
• W2919467874 doi "https://doi.org/10.1113/jp277254" @default.
• W2919467874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30829392" @default.
• W2919467874 hasPublicationYear "2019" @default.
• W2919467874 type Work @default.
• W2919467874 sameAs 2919467874 @default.
• W2919467874 citedByCount "23" @default.
• W2919467874 countsByYear W29194678742019 @default.
• W2919467874 countsByYear W29194678742020 @default.
• W2919467874 countsByYear W29194678742021 @default.
• W2919467874 countsByYear W29194678742022 @default.
• W2919467874 countsByYear W29194678742023 @default.
• W2919467874 crossrefType "journal-article" @default.
• W2919467874 hasAuthorship W2919467874A5015396887 @default.
• W2919467874 hasAuthorship W2919467874A5041603810 @default.
• W2919467874 hasAuthorship W2919467874A5045487548 @default.
• W2919467874 hasAuthorship W2919467874A5046877063 @default.
• W2919467874 hasAuthorship W2919467874A5060019261 @default.
• W2919467874 hasBestOaLocation W29194678741 @default.
• W2919467874 hasConcept C126322002 @default.
• W2919467874 hasConcept C142724271 @default.
• W2919467874 hasConcept C150903083 @default.
• W2919467874 hasConcept C163415756 @default.
• W2919467874 hasConcept C164705383 @default.
• W2919467874 hasConcept C181152851 @default.
• W2919467874 hasConcept C207001950 @default.
• W2919467874 hasConcept C2776359302 @default.
• W2919467874 hasConcept C2777953023 @default.
• W2919467874 hasConcept C2780447015 @default.
• W2919467874 hasConcept C39133596 @default.
• W2919467874 hasConcept C42219234 @default.
• W2919467874 hasConcept C71924100 @default.
• W2919467874 hasConcept C84393581 @default.
• W2919467874 hasConcept C86803240 @default.
• W2919467874 hasConceptScore W2919467874C126322002 @default.
• W2919467874 hasConceptScore W2919467874C142724271 @default.
• W2919467874 hasConceptScore W2919467874C150903083 @default.
• W2919467874 hasConceptScore W2919467874C163415756 @default.
• W2919467874 hasConceptScore W2919467874C164705383 @default.
• W2919467874 hasConceptScore W2919467874C181152851 @default.
• W2919467874 hasConceptScore W2919467874C207001950 @default.
• W2919467874 hasConceptScore W2919467874C2776359302 @default.
• W2919467874 hasConceptScore W2919467874C2777953023 @default.
• W2919467874 hasConceptScore W2919467874C2780447015 @default.
• W2919467874 hasConceptScore W2919467874C39133596 @default.
• W2919467874 hasConceptScore W2919467874C42219234 @default.
• W2919467874 hasConceptScore W2919467874C71924100 @default.
• W2919467874 hasConceptScore W2919467874C84393581 @default.
• W2919467874 hasConceptScore W2919467874C86803240 @default.
• W2919467874 hasFunder F4320320924 @default.
• W2919467874 hasFunder F4320334678 @default.
• W2919467874 hasIssue "11" @default.
• W2919467874 hasLocation W29194678741 @default.
• W2919467874 hasLocation W29194678742 @default.
• W2919467874 hasOpenAccess W2919467874 @default.
• W2919467874 hasPrimaryLocation W29194678741 @default.
• W2919467874 hasRelatedWork W1933144109 @default.

• next