FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919491176> ?p ?o ?g. }

• W2919491176 abstract "Conformational conversion of the cellular isoform of prion protein, PrPC, into the abnormally folded, amyloidogenic isoform, PrPSc, is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. We previously reported that the octapeptide repeat (OR) region could be dispensable for converting PrPC into PrPSc after infection with RML prions. We demonstrated that mice transgenically expressing mouse PrP with deletion of the OR region on the PrP knockout background, designated Tg(PrPΔOR)/Prnp0/0 mice, did not show reduced susceptibility to RML scrapie prions, with abundant accumulation of PrPScΔOR in their brains. We show here that Tg(PrPΔOR)/Prnp0/0 mice were highly resistant to BSE prions, developing the disease with markedly elongated incubation times after infection with BSE prions. The conversion of PrPΔOR into PrPScΔOR was markedly delayed in their brains. These results suggest that the OR region may have a crucial role in the conversion of PrPC into PrPSc after infection with BSE prions. However, Tg(PrPΔOR)/Prnp0/0 mice remained susceptible to RML and 22L scrapie prions, developing the disease without elongated incubation times after infection with RML and 22L prions. PrPScΔOR accumulated only slightly less in the brains of RML- or 22L-infected Tg(PrPΔOR)/Prnp0/0 mice than PrPSc in control wild-type mice. Taken together, these results indicate that the OR region of PrPC could play a differential role in the pathogenesis of BSE prions and RML or 22L scrapie prions.IMPORTANCE Structure-function relationship studies of PrPC conformational conversion into PrPSc are worthwhile to understand the mechanism of the conversion of PrPC into PrPSc We show here that, by inoculating Tg(PrPΔOR)/Prnp0/0 mice with the three different strains of RML, 22L, and BSE prions, the OR region could play a differential role in the conversion of PrPC into PrPSc after infection with RML or 22L scrapie prions and BSE prions. PrPΔOR was efficiently converted into PrPScΔOR after infection with RML and 22L prions. However, the conversion of PrPΔOR into PrPScΔOR was markedly delayed after infection with BSE prions. Further investigation into the role of the OR region in the conversion of PrPC into PrPSc after infection with BSE prions might be helpful for understanding the pathogenesis of BSE prions." @default.
• W2919491176 created "2019-03-11" @default.
• W2919491176 creator A5005879454 @default.
• W2919491176 creator A5016716688 @default.
• W2919491176 creator A5020639857 @default.
• W2919491176 creator A5056969491 @default.
• W2919491176 creator A5061779784 @default.
• W2919491176 creator A5065970024 @default.
• W2919491176 creator A5067479944 @default.
• W2919491176 creator A5068390829 @default.
• W2919491176 creator A5071019088 @default.
• W2919491176 creator A5081382521 @default.
• W2919491176 date "2018-01-01" @default.
• W2919491176 modified "2023-10-18" @default.
• W2919491176 title "Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice" @default.
• W2919491176 cites W149247114 @default.
• W2919491176 cites W1501494207 @default.
• W2919491176 cites W1521798537 @default.
• W2919491176 cites W1549404680 @default.
• W2919491176 cites W1563777667 @default.
• W2919491176 cites W1591693496 @default.
• W2919491176 cites W1619710608 @default.
• W2919491176 cites W1704732331 @default.
• W2919491176 cites W1938969372 @default.
• W2919491176 cites W1966382960 @default.
• W2919491176 cites W1966848792 @default.
• W2919491176 cites W1967542948 @default.
• W2919491176 cites W1968458490 @default.
• W2919491176 cites W1973510262 @default.
• W2919491176 cites W1977614131 @default.
• W2919491176 cites W1985031015 @default.
• W2919491176 cites W1989150559 @default.
• W2919491176 cites W2001002729 @default.
• W2919491176 cites W2019262753 @default.
• W2919491176 cites W2029822288 @default.
• W2919491176 cites W2042978244 @default.
• W2919491176 cites W2044004977 @default.
• W2919491176 cites W2044246933 @default.
• W2919491176 cites W2053636966 @default.
• W2919491176 cites W2058659733 @default.
• W2919491176 cites W2060193071 @default.
• W2919491176 cites W2078982166 @default.
• W2919491176 cites W2089320434 @default.
• W2919491176 cites W2098281734 @default.
• W2919491176 cites W2109401365 @default.
• W2919491176 cites W2121611717 @default.
• W2919491176 cites W2125433371 @default.
• W2919491176 cites W2126066596 @default.
• W2919491176 cites W2138768135 @default.
• W2919491176 cites W2138889916 @default.
• W2919491176 cites W2151377870 @default.
• W2919491176 cites W2152131599 @default.
• W2919491176 cites W2166526845 @default.
• W2919491176 cites W2168650526 @default.
• W2919491176 cites W2324660492 @default.
• W2919491176 doi "https://doi.org/10.1128/jvi.01368-17" @default.
• W2919491176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5730770" @default.
• W2919491176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29046443" @default.
• W2919491176 hasPublicationYear "2018" @default.
• W2919491176 type Work @default.
• W2919491176 sameAs 2919491176 @default.
• W2919491176 citedByCount "14" @default.
• W2919491176 countsByYear W29194911762020 @default.
• W2919491176 countsByYear W29194911762021 @default.
• W2919491176 countsByYear W29194911762022 @default.
• W2919491176 countsByYear W29194911762023 @default.
• W2919491176 crossrefType "journal-article" @default.
• W2919491176 hasAuthorship W2919491176A5005879454 @default.
• W2919491176 hasAuthorship W2919491176A5016716688 @default.
• W2919491176 hasAuthorship W2919491176A5020639857 @default.
• W2919491176 hasAuthorship W2919491176A5056969491 @default.
• W2919491176 hasAuthorship W2919491176A5061779784 @default.
• W2919491176 hasAuthorship W2919491176A5065970024 @default.
• W2919491176 hasAuthorship W2919491176A5067479944 @default.
• W2919491176 hasAuthorship W2919491176A5068390829 @default.
• W2919491176 hasAuthorship W2919491176A5071019088 @default.
• W2919491176 hasAuthorship W2919491176A5081382521 @default.
• W2919491176 hasBestOaLocation W29194911761 @default.
• W2919491176 hasConcept C104317684 @default.
• W2919491176 hasConcept C142724271 @default.
• W2919491176 hasConcept C143701427 @default.
• W2919491176 hasConcept C148632171 @default.
• W2919491176 hasConcept C159047783 @default.
• W2919491176 hasConcept C203014093 @default.
• W2919491176 hasConcept C2522874641 @default.
• W2919491176 hasConcept C25642318 @default.
• W2919491176 hasConcept C2776735649 @default.
• W2919491176 hasConcept C2776797465 @default.
• W2919491176 hasConcept C2779134260 @default.
• W2919491176 hasConcept C2780727368 @default.
• W2919491176 hasConcept C2780942790 @default.
• W2919491176 hasConcept C2781131914 @default.
• W2919491176 hasConcept C3019804061 @default.
• W2919491176 hasConcept C53345823 @default.
• W2919491176 hasConcept C54355233 @default.
• W2919491176 hasConcept C55493867 @default.
• W2919491176 hasConcept C71924100 @default.
• W2919491176 hasConcept C86803240 @default.
• W2919491176 hasConceptScore W2919491176C104317684 @default.
• W2919491176 hasConceptScore W2919491176C142724271 @default.

• next