FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2919632660> ?p ?o ?g. }

• W2919632660 endingPage "837" @default.
• W2919632660 startingPage "829" @default.
• W2919632660 abstract "Abstract Background The “atopic march” has been considered a linear progression starting with eczema and culminating with development of asthma. Not all asthma cases, however, are preceded by eczema, and not all children with eczema go on to develop asthma. Objective The aim of this study was to explore the impact of allergic sensitization patterns on the association between early eczema and later childhood asthma. Given the numerous reported associations of the ciliary gene KIF3A with the atopic march, we also examined the impact of KIF3A risk allele rs12186803 on our analyses. Methods We studied 505 participants in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a prospective birth cohort, with longitudinal eczema and asthma outcomes as well as prospective data regarding timing of sensitization to foods and aeroallergens. KIF3A genotypes were available on all children. Results Two high‐risk groups were identified: one with and one without early eczema. The high‐risk group with early eczema was more likely to be sensitized to food allergens, while the group without early eczema was more likely to be polysensitized to aeroallergens. The KIF3A rs12186803 risk allele interacted with food sensitization to increase asthma risk in children with eczema ( P = 0.02). In children without eczema, asthma was associated with the interaction between rs12186803 and aeroallergen sensitization ( P = 0.007). Conclusions & Clinical Relevance KIF3A interacted differentially with sensitization pattern to increase the risk of asthma in two high‐risk groups of children with and without early eczema. Given the reported role of KIF3A in epithelial cell functioning, the results add evidence to the hypothesis that an impaired epithelial barrier is a key aspect in the development of allergic disease." @default.
• W2919632660 created "2019-03-11" @default.
• W2919632660 creator A5023724713 @default.
• W2919632660 creator A5026254160 @default.
• W2919632660 creator A5027084552 @default.
• W2919632660 creator A5037499657 @default.
• W2919632660 creator A5038372761 @default.
• W2919632660 creator A5066740518 @default.
• W2919632660 creator A5071603262 @default.
• W2919632660 creator A5076369901 @default.
• W2919632660 creator A5090332369 @default.
• W2919632660 date "2019-03-27" @default.
• W2919632660 modified "2023-10-12" @default.
• W2919632660 title "Identification of two early life eczema and non‐eczema phenotypes with high risk for asthma development" @default.
• W2919632660 cites W1954923955 @default.
• W2919632660 cites W1979901338 @default.
• W2919632660 cites W1982001659 @default.
• W2919632660 cites W1983108554 @default.
• W2919632660 cites W1988242006 @default.
• W2919632660 cites W1999158481 @default.
• W2919632660 cites W1999690368 @default.
• W2919632660 cites W2009104876 @default.
• W2919632660 cites W2027262352 @default.
• W2919632660 cites W2042588031 @default.
• W2919632660 cites W2046484714 @default.
• W2919632660 cites W2047740029 @default.
• W2919632660 cites W2063976877 @default.
• W2919632660 cites W2066163428 @default.
• W2919632660 cites W2068268864 @default.
• W2919632660 cites W2077182790 @default.
• W2919632660 cites W2078761628 @default.
• W2919632660 cites W2088679944 @default.
• W2919632660 cites W2090937345 @default.
• W2919632660 cites W2095417811 @default.
• W2919632660 cites W2099529808 @default.
• W2919632660 cites W2100023548 @default.
• W2919632660 cites W2102286635 @default.
• W2919632660 cites W2103169988 @default.
• W2919632660 cites W2119500561 @default.
• W2919632660 cites W2124573427 @default.
• W2919632660 cites W2130692707 @default.
• W2919632660 cites W2132372821 @default.
• W2919632660 cites W2134902690 @default.
• W2919632660 cites W2138545858 @default.
• W2919632660 cites W2150825072 @default.
• W2919632660 cites W2165827077 @default.
• W2919632660 cites W2168172742 @default.
• W2919632660 cites W2173807505 @default.
• W2919632660 cites W2176032417 @default.
• W2919632660 cites W2279757418 @default.
• W2919632660 cites W2312397711 @default.
• W2919632660 cites W2517875580 @default.
• W2919632660 cites W2546144291 @default.
• W2919632660 cites W2589250862 @default.
• W2919632660 cites W2623738179 @default.
• W2919632660 cites W2742112529 @default.
• W2919632660 cites W2786087368 @default.
• W2919632660 doi "https://doi.org/10.1111/cea.13379" @default.
• W2919632660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546546" @default.
• W2919632660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30830718" @default.
• W2919632660 hasPublicationYear "2019" @default.
• W2919632660 type Work @default.
• W2919632660 sameAs 2919632660 @default.
• W2919632660 citedByCount "8" @default.
• W2919632660 countsByYear W29196326602020 @default.
• W2919632660 countsByYear W29196326602021 @default.
• W2919632660 countsByYear W29196326602022 @default.
• W2919632660 crossrefType "journal-article" @default.
• W2919632660 hasAuthorship W2919632660A5023724713 @default.
• W2919632660 hasAuthorship W2919632660A5026254160 @default.
• W2919632660 hasAuthorship W2919632660A5027084552 @default.
• W2919632660 hasAuthorship W2919632660A5037499657 @default.
• W2919632660 hasAuthorship W2919632660A5038372761 @default.
• W2919632660 hasAuthorship W2919632660A5066740518 @default.
• W2919632660 hasAuthorship W2919632660A5071603262 @default.
• W2919632660 hasAuthorship W2919632660A5076369901 @default.
• W2919632660 hasAuthorship W2919632660A5090332369 @default.
• W2919632660 hasBestOaLocation W29196326602 @default.
• W2919632660 hasConcept C126322002 @default.
• W2919632660 hasConcept C188816634 @default.
• W2919632660 hasConcept C203014093 @default.
• W2919632660 hasConcept C207480886 @default.
• W2919632660 hasConcept C2776042228 @default.
• W2919632660 hasConcept C2776217527 @default.
• W2919632660 hasConcept C2777697326 @default.
• W2919632660 hasConcept C2778329239 @default.
• W2919632660 hasConcept C2778391694 @default.
• W2919632660 hasConcept C2780510475 @default.
• W2919632660 hasConcept C71924100 @default.
• W2919632660 hasConceptScore W2919632660C126322002 @default.
• W2919632660 hasConceptScore W2919632660C188816634 @default.
• W2919632660 hasConceptScore W2919632660C203014093 @default.
• W2919632660 hasConceptScore W2919632660C207480886 @default.
• W2919632660 hasConceptScore W2919632660C2776042228 @default.
• W2919632660 hasConceptScore W2919632660C2776217527 @default.
• W2919632660 hasConceptScore W2919632660C2777697326 @default.
• W2919632660 hasConceptScore W2919632660C2778329239 @default.
• W2919632660 hasConceptScore W2919632660C2778391694 @default.

• next