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- W2919904819 abstract "Stress granule formation is important for stress response in normal cells and could lead to chemotherapy resistance in cancer cells. Aberrant stress granule dynamics are also known to disrupt proteostasis, affect RNA metabolism, and contribute to neuronal cell death. Meanwhile, circadian abnormality is an aging-related risk factor for cancer and neurodegeneration. Whether stress granule dynamics are circadian regulated is entirely unknown. Here we show that the formation of stress granules varied by zeitgeber time in mouse liver. Moreover, altering circadian regulation by silencing the core circadian gene Bmal1 in a cell line expressing an endogenous GFP-tagged G3BP1 significantly increased stress granule dynamics, while the overexpression of Bmal1 decreased them. Surprisingly, increased stress granule dynamics and formation by transient decrease of BMAL1 coincided with increased resistance to stress-induced cell death. The circadian regulation of stress granules was mediated by oscillating eIF2α expression. At zeitgeber time when BMAL1 and eIF2α were at nadir, reduction of unphosphorylated eIF2α could significantly alter the ratio of phosphorylated/total eIF2α and quickly lead to increased formation of stress granules. Therefore, diurnal oscillating eIF2α connects the circadian cue to a cellular stress response mechanism that is vital for both neurodegeneration and cancer." @default.
- W2919904819 created "2019-03-11" @default.
- W2919904819 creator A5038119377 @default.
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- W2919904819 date "2019-03-04" @default.
- W2919904819 modified "2023-10-08" @default.
- W2919904819 title "Circadian control of stress granules by oscillating EIF2α" @default.
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- W2919904819 cites W1930786993 @default.
- W2919904819 cites W1964072966 @default.
- W2919904819 cites W1973109217 @default.
- W2919904819 cites W1977504104 @default.
- W2919904819 cites W1983633543 @default.
- W2919904819 cites W1988968354 @default.
- W2919904819 cites W1993901564 @default.
- W2919904819 cites W1995200202 @default.
- W2919904819 cites W1999022886 @default.
- W2919904819 cites W2003062381 @default.
- W2919904819 cites W2003618511 @default.
- W2919904819 cites W2004369408 @default.
- W2919904819 cites W2004498120 @default.
- W2919904819 cites W2004850573 @default.
- W2919904819 cites W2016332933 @default.
- W2919904819 cites W2016428557 @default.
- W2919904819 cites W2018342523 @default.
- W2919904819 cites W2023689431 @default.
- W2919904819 cites W2027410128 @default.
- W2919904819 cites W2031964319 @default.
- W2919904819 cites W2039639342 @default.
- W2919904819 cites W2040446048 @default.
- W2919904819 cites W2041323735 @default.
- W2919904819 cites W2044627978 @default.
- W2919904819 cites W2044821390 @default.
- W2919904819 cites W2050234043 @default.
- W2919904819 cites W2051470096 @default.
- W2919904819 cites W2054425157 @default.
- W2919904819 cites W2055379075 @default.
- W2919904819 cites W2056265088 @default.
- W2919904819 cites W2056598650 @default.
- W2919904819 cites W2065148518 @default.
- W2919904819 cites W2066107559 @default.
- W2919904819 cites W2069351898 @default.
- W2919904819 cites W2072281823 @default.
- W2919904819 cites W2074726646 @default.
- W2919904819 cites W2083278580 @default.
- W2919904819 cites W2084459589 @default.
- W2919904819 cites W2098064548 @default.
- W2919904819 cites W2104290916 @default.
- W2919904819 cites W2108988707 @default.
- W2919904819 cites W2110739636 @default.
- W2919904819 cites W2121847288 @default.
- W2919904819 cites W2133918896 @default.
- W2919904819 cites W2136057227 @default.
- W2919904819 cites W2137252071 @default.
- W2919904819 cites W2139669192 @default.
- W2919904819 cites W2143210222 @default.
- W2919904819 cites W2150523249 @default.
- W2919904819 cites W2154945114 @default.
- W2919904819 cites W2159354359 @default.
- W2919904819 cites W2164824098 @default.
- W2919904819 cites W2236156346 @default.
- W2919904819 cites W2259520888 @default.
- W2919904819 cites W2265211954 @default.
- W2919904819 cites W2392382529 @default.
- W2919904819 cites W2407890715 @default.
- W2919904819 cites W2416403255 @default.
- W2919904819 cites W2514004327 @default.
- W2919904819 cites W2533664860 @default.
- W2919904819 cites W2553026365 @default.
- W2919904819 cites W2566818766 @default.
- W2919904819 cites W2567503091 @default.
- W2919904819 cites W2605064087 @default.
- W2919904819 cites W2616802735 @default.
- W2919904819 cites W2738794221 @default.
- W2919904819 cites W2748311674 @default.
- W2919904819 cites W2766968224 @default.
- W2919904819 cites W2773188027 @default.
- W2919904819 cites W2787429377 @default.
- W2919904819 cites W2794425153 @default.
- W2919904819 cites W2794768252 @default.
- W2919904819 cites W2796205057 @default.
- W2919904819 cites W2801070441 @default.
- W2919904819 cites W2884041434 @default.
- W2919904819 cites W2892231379 @default.
- W2919904819 cites W2895371277 @default.
- W2919904819 cites W3173662029 @default.
- W2919904819 doi "https://doi.org/10.1038/s41419-019-1471-y" @default.
- W2919904819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6399301" @default.
- W2919904819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30833545" @default.
- W2919904819 hasPublicationYear "2019" @default.
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