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• W2919987102 startingPage "1407" @default.
• W2919987102 abstract "Oncolytic virotherapy (OVT) is a promising approach in which WT or engineered viruses selectively replicate and destroy tumor cells while sparing normal ones. In the last two decades, different oncolytic viruses (OVs) have been modified and tested in a number of preclinical studies, some of which have led to clinical trials in cancer patients. These clinical trials have revealed several critical limitations with regard to viral delivery, spread, resistance, and antiviral immunity. Here, we focus on promising research strategies that have been developed to overcome the aforementioned obstacles. Such strategies include engineering OVs to target a broad spectrum of tumor cells while evading the immune system, developing unique delivery mechanisms, combining other immunotherapeutic agents with OVT, and using clinically translatable mouse tumor models to potentially translate OVT more readily into clinical settings." @default.
• W2919987102 created "2019-03-11" @default.
• W2919987102 creator A5034567480 @default.
• W2919987102 creator A5037465312 @default.
• W2919987102 creator A5056433769 @default.
• W2919987102 creator A5090355682 @default.
• W2919987102 date "2019-03-04" @default.
• W2919987102 modified "2023-10-15" @default.
• W2919987102 title "Oncolytic viruses: overcoming translational challenges" @default.
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